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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Intrahypothalamic injection of deltorphin-II alters body temperature in rats.

The present study investigated the effect of H-Try-d-Ala-Phe-Glu-Val-Gly-NH2 deltorphin-II, a selective delta-2 agonist, and [d-Pen(2),d-Pen(5)]enkephalin, a selective delta-1 agonist, on body temperature in the rat. Microinjected into the preoptic anterior hypothalamus (POAH), deltorphin-II (0.1-1 microg) produced an immediate dose-related hyperthermia following injection. Injection of the delta-2 antagonist naltriben into the preoptic anterior hypothalamus (1 microg, 30 min prior to deltorphin-II) significantly attenuated the deltorphin-II-induced hyperthermia. Microinjection of [d-Pen(2),d-Pen(5)]enkephalin into the POAH (0.1-3 microg) did not affect Tb. The data demonstrate that delta-2 receptors are involved in the mediation of Tb effects, and deltorphin-II exerts its action directly on thermosensitive cells of the preoptic anterior hypothalamus. Delta-1 opioid receptors do not appear to be involved in the control of body temperature.[1]


  1. Intrahypothalamic injection of deltorphin-II alters body temperature in rats. Benamar, K., Rawls, S.M., Geller, E.B., Adler, M.W. Brain Res. (2004) [Pubmed]
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