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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Rapid induction of glomerular lipidosis in APA hamsters by streptozotocin.

The pathology of male Syrian hamsters of APA strain which were injected intraperitoneally with 40 mg/kg body weight of streptozotocin (SZ) at 2 months of age was examined. It showed long-lasting prominent hyperglycaemia and hyperlipidaemia with glucosuria and the development of glomerular lipidosis from 1 month after SZ-injection (1 MAI). Glomerular lesions were restricted to the juxtamedullary cortex at 1 MAI and then extended to the subcapsular cortex. At 3 MAI, glomerular lesions were characterized by focal segmental glomerulosclerosis showing segmental expansion of the mesangial area due to an increase of basement membrane-like material and mesangial cells with lipid droplets and foam cells. SZ-induced diabetic APA hamsters will be a useful model for the investigation of glomerular lipidosis and focal segmental glomerulosclerosis.[1]


  1. Rapid induction of glomerular lipidosis in APA hamsters by streptozotocin. Han, J.S., Sugawara, Y., Doi, K. International journal of experimental pathology. (1992) [Pubmed]
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