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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Integrin-linked kinase: integrin's mysterious partner.

Integrin-mediated cell adhesion regulates a vast number of biological processes including migration, survival and proliferation of cells. It is therefore not surprising that defects in integrin function are often rate-limiting for development and profoundly affect the progression of several diseases. The functions of integrins are mediated through the recruitment of cytoplasmic plaque proteins. One of these is integrin-linked kinase, which connects integrins to the actin cytoskeleton and transduces signals through integrins to the extracellular matrix and from integrins to various subcellular compartments.[1]

References

  1. Integrin-linked kinase: integrin's mysterious partner. Grashoff, C., Thievessen, I., Lorenz, K., Ussar, S., Fässler, R. Curr. Opin. Cell Biol. (2004) [Pubmed]
 
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