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Imaizumi, T. et al.

Imaizumi, Hatakeyama, Yamashita, Yoshida, Ishikawa, Taima, Satoh, Mori, Wakabayashi,

Interferon-gamma induces retinoic acid-inducible gene-I in endothelial cells.

Interferon-gamma (IFN-gamma) induces expression of multiple genes in endothelial cells. Retinoic acid-inducible gene-I (RIG-I) encodes a protein belonging to the DExH-box family, but details of its physiological function are not clear. RIG-I is induced in leukemia cells by retinoic acid and in endothelial cells by lipopolysaccharide. In the present study, the authors found that IFN-gamma also induces the expression of RIG-I in human umbilical vein endothelial cells. Induction of RIG-I mRNA by IFN-gamma was not altered by the treatment with cycloheximide or interleukin-4. Fluorescent immunostaining and Western blot analysis revealed cytoplasmic distribution of RIG-I. The in situ endothelium in a normal lung tissue was also found to express RIG-I protein. Although the physiological function of RIG-I is still unknown, induction of RIG-I by IFN-gamma may play an important role in inflammatory or immunological reactions in endothelial cells.[1]

References

Interferon-gamma induces retinoic acid-inducible gene-I in endothelial cells. Imaizumi, T., Hatakeyama, M., Yamashita, K., Yoshida, H., Ishikawa, A., Taima, K., Satoh, K., Mori, F., Wakabayashi, K. Endothelium (2004) [Pubmed]

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