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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Effect of the flavonol quercetin on membrane conductances in rat colonic crypt cells.

The plant polyphenol quercetin was shown to induce Cl- secretion in rat colon. This study was performed to investigate the alterations of membrane conductances in isolated epithelial cells induced by quercetin. Whole-cell patch-clamp recordings were performed in isolated crypts from rat distal colon. In cells of the crypt basis, quercetin significantly hyperpolarized the membrane potential at concentrations > or =3 microM and increased the K+ conductance without visibly altering the Cl- conductance. Thus, quercetin induces Cl- secretion merely by activation of K+ channels in the colon epithelium.[1]

References

  1. Effect of the flavonol quercetin on membrane conductances in rat colonic crypt cells. Cermak, R., Wolffram, S., Kuhn, G. Eur. J. Pharmacol. (2004) [Pubmed]
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