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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Fiebich, B.L. et al.

Fiebich, Akundi, Seidel, Geyer, Haus, Müller, Stratz, Candelario-Jalil,

Expression of 5-HT3A receptors in cells of the immune system.

There is evidence from both human and animal research that 5-hydroxytryptamine3 (5-HT3) receptor antagonists, particularly tropisetron, exert analgesic and antiinflammatory effects. However, the underlying mechanisms of these effects including the expression of 5-HT3 receptors in cells of the immune system have not yet been investigated in detail. Therefore, we investigated the expression of the 5-HT3A receptor in primary human monocytes, chondrocytes, T-cells, dendritic cells, and synovial tissue. We found that 5-HT3A receptors are expressed in monocytes, chondrocytes, T-cells, and synovial tissue but not in dendritic cells. Our data show that 5-HT3A receptors are widely expressed in cells of the immune system and that they might play an important role in inflammatory events and in the observed antiphlogistic effects of 5-HT3 receptor antagonists.[1]

References

Expression of 5-HT3A receptors in cells of the immune system. Fiebich, B.L., Akundi, R.S., Seidel, M., Geyer, V., Haus, U., Müller, W., Stratz, T., Candelario-Jalil, E. Scand. J. Rheumatol. Suppl. (2004) [Pubmed]

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