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MeSH Review

Animal Experimentation

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Disease relevance of Animal Experimentation


Psychiatry related information on Animal Experimentation


High impact information on Animal Experimentation


Chemical compound and disease context of Animal Experimentation


Biological context of Animal Experimentation


Anatomical context of Animal Experimentation


Associations of Animal Experimentation with chemical compounds


Gene context of Animal Experimentation

  • Animal experiments including transgenic and knockout mice suggest that three isoforms, SREBP-1a, -1c, and -2, have different roles in lipid synthesis [35].
  • Current data on the gastric safety of cyclooxygenase-2 (COX-2) inhibitors in the presence of H. pylori infection are largely derived from animal experiments and indirect clinical evidence [36].
  • Our animal experiments further revealed that an additional administration of a high-dose ethanol to chronic alcohol-fed rats led to decrease of endotoxin clearance, increased extrahepatic accumulation of endotoxin and elevation of plasma TNF [37].
  • Animal experiments using antisense oligodeoxynucleotides directed against the mRNA of both CRH receptor subtypes identified the CRH1 receptor as the mediator of the anxiogenic effects of CRH [38].
  • Immunohistochemical and molecular studies of endometrial NOS expression, as well as animal experiments with NOS inhibitors, indicate that NO plays an important role in endometrial functions such as endometrial receptivity, implantation and menstruation [39].

Analytical, diagnostic and therapeutic context of Animal Experimentation


  1. Prostaglandin H synthase 2 is expressed abnormally in human colon cancer: evidence for a transcriptional effect. Kutchera, W., Jones, D.A., Matsunami, N., Groden, J., McIntyre, T.M., Zimmerman, G.A., White, R.L., Prescott, S.M. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  2. Expression of adhesion molecules on circulating polymorphonuclear leukocytes during orthotopic liver transplantation. Thiel, M., Imendörffer, S., Chouker, A., Groh, J., Briegel, J., Anthuber, M., Krämling, H.J., Arfors, K.E., Peter, K., Messmer, K. Hepatology (1998) [Pubmed]
  3. Reserpine treatment of Raynaud's disease. Nobin, B.A., Nielsen, S.L., Eklov, B., Lassen, N.A. Ann. Surg. (1978) [Pubmed]
  4. Vinyl chloride-a classical industrial toxicant of new interest. Bolt, H.M. Crit. Rev. Toxicol. (2005) [Pubmed]
  5. Dexmedetomidine-induced stimulation of glutamine oxidation in astrocytes: a possible mechanism for its neuroprotective activity. Huang, R., Chen, Y., Yu, A.C., Hertz, L. J. Cereb. Blood Flow Metab. (2000) [Pubmed]
  6. A single high dose of dizocilpine produces long-lasting impairment of the water maze performance in adult rats. Lukoyanov, N.V., Paula-Barbosa, M.M. Neurosci. Lett. (2000) [Pubmed]
  7. Creatine supplementation lowers brain glutamate levels in Huntington's disease. Bender, A., Auer, D.P., Merl, T., Reilmann, R., Saemann, P., Yassouridis, A., Bender, J., Weindl, A., Dose, M., Gasser, T., Klopstock, T. J. Neurol. (2005) [Pubmed]
  8. Effects of ethanol exposure on the embryo-fetus: experimental considerations, mechanisms, and the role of prostaglandins. Smith, G.N., Patrick, J., Sinervo, K.R., Brien, J.F. Can. J. Physiol. Pharmacol. (1991) [Pubmed]
  9. Subjective effects of slow-release bupropion versus caffeine as determined in a quasi-naturalistic setting. Zernig, G., De Wit, H., Telser, S., Nienhusmeier, M., Wakonigg, G., Sturm, K., Berger, I., Kemmler, G., Saria, A. Pharmacology (2004) [Pubmed]
  10. Hyperalimentation in cancer. Souba, W.W., Copeland, E.M. CA: a cancer journal for clinicians. (1989) [Pubmed]
  11. Animal research. Challenge on testing. Anderson, C. Nature (1991) [Pubmed]
  12. Animal research. White House says no. Anderson, G.C. Nature (1990) [Pubmed]
  13. Androgens and coronary artery disease. Wu, F.C., von Eckardstein, A. Endocr. Rev. (2003) [Pubmed]
  14. Opiate withdrawal in utero increases neonatal morbidity in the rat. Lichtblau, L., Sparber, S.B. Science (1981) [Pubmed]
  15. Antimigraine drug sumatriptan increases blood flow velocity in large cerebral arteries during migraine attacks. Caekebeke, J.F., Ferrari, M.D., Zwetsloot, C.P., Jansen, J., Saxena, P.R. Neurology (1992) [Pubmed]
  16. Cholestatic effects of cyclosporine in the rat. Chan, F.K., Shaffer, E.A. Transplantation (1997) [Pubmed]
  17. Serum progesterone levels correlate with decreased cerebral edema after traumatic brain injury in male rats. Wright, D.W., Bauer, M.E., Hoffman, S.W., Stein, D.G. J. Neurotrauma (2001) [Pubmed]
  18. The effects of acetaldehyde and 2,3-butanediol on rat embryos developing in vitro. Priscott, P.K. Biochem. Pharmacol. (1985) [Pubmed]
  19. Structural correlations with cross-reactivity of beta-lactam antibiotics in delayed type hypersensitivity. Cross-allergenicity in hypersensitivity to cephems with a tetrazolyl group in the C-3 side chain. Uno, K., Yamasaku, F. J. Antimicrob. Chemother. (1989) [Pubmed]
  20. Inactivation of nuclear factor kappaB by soy isoflavone genistein contributes to increased apoptosis induced by chemotherapeutic agents in human cancer cells. Li, Y., Ahmed, F., Ali, S., Philip, P.A., Kucuk, O., Sarkar, F.H. Cancer Res. (2005) [Pubmed]
  21. Intraluminal capsaicin does not affect fluid and electrolyte absorption in the human jejunum but does cause pain. Hammer, J., Hammer, H.F., Eherer, A.J., Petritsch, W., Holzer, P., Krejs, G.J. Gut (1998) [Pubmed]
  22. Fusion PCR generated Japanese encephalitis virus/dengue 4 virus chimera exhibits lack of neuroinvasiveness, attenuated neurovirulence, and a dual-flavi immune response in mice. Mathenge, E.G., Parquet, M.d.e.l. .C., Funakoshi, Y., Houhara, S., Wong, P.F., Ichinose, A., Hasebe, F., Inoue, S., Morita, K. J. Gen. Virol. (2004) [Pubmed]
  23. Mild hypothermia can enhance pial arteriolar vasodilation induced by isoflurane and sevoflurane in cats. Inoue, S., Kawaguchi, M., Kurehara, K., Sakamoto, T., Kishi, K., Einaga, T., Kitaguchi, K., Furuya, H. Crit. Care Med. (2002) [Pubmed]
  24. Combined intravenous lidocaine and inhaled salbutamol protect against bronchial hyperreactivity more effectively than lidocaine or salbutamol alone. Groeben, H., Silvanus, M.T., Beste, M., Peters, J. Anesthesiology (1998) [Pubmed]
  25. Arginine vasopressin enhances sympathetic constriction through the V1 vasopressin receptor in human saphenous vein. Medina, P., Acuña, A., Martínez-León, J.B., Otero, E., Vila, J.M., Aldasoro, M., Lluch, S. Circulation (1998) [Pubmed]
  26. Enhanced immunity by NeuEDhsp70 DNA vaccine Is needed to combat an aggressive spontaneous metastatic breast cancer. Kim, J.H., Majumder, N., Lin, H., Chen, J., Falo, L.D., You, Z. Mol. Ther. (2005) [Pubmed]
  27. Comparison of adrenal functions in kidney transplant recipients with different long-term immunosuppressive treatments--prednisolone and azathioprine versus prednisolone and cyclosporine. Oka, K., Shimodaira, H., Hirano, T., Sakurai, E., Tamaki, T., Kozaki, M. Transplantation (1993) [Pubmed]
  28. Tonic neck reflexes on upper limb flexor tone in man. Aiello, I., Rosati, G., Sau, G.F., Patraskakis, S., Bissakou, M., Traccis, S. Exp. Neurol. (1988) [Pubmed]
  29. Changes in oxygen tension and effects on cyclooxygenase metabolites: III. Decrease of retinal prostacyclin in kittens exposed to hyperoxia. Stuart, M.J., Phelps, D.L., Setty, B.N. Pediatrics (1988) [Pubmed]
  30. Interactions between glutamatergic and monoaminergic systems within the basal ganglia--implications for schizophrenia and Parkinson's disease. Carlsson, M., Carlsson, A. Trends Neurosci. (1990) [Pubmed]
  31. Cholesterol and violence: is there a connection? Golomb, B.A. Ann. Intern. Med. (1998) [Pubmed]
  32. Sustained local drug delivery from a radiopaque implanted reservoir. Koole, L.H., Kruft, M.A., Aldenhoff, Y.B., van 't Oost, N.E., van Kroonenburgh, M.J., van der Veen, F.H. Nat. Biotechnol. (1998) [Pubmed]
  33. Fibronectin and its integrin receptors in cancer. Ruoslahti, E. Adv. Cancer Res. (1999) [Pubmed]
  34. Antipsychotic properties of Des-enkephalin-gamma-endorphin in treatment of schizophrenic patients. Verhoeven, W.M., van Ree, J.M., Heezius-van Bentum, A., de Wied, D., van Praag, H.M. Arch. Gen. Psychiatry (1982) [Pubmed]
  35. Sterol regulatory element-binding protein family as global regulators of lipid synthetic genes in energy metabolism. Shimano, H. Vitam. Horm. (2002) [Pubmed]
  36. COX-2 inhibition, H. pylori infection and the risk of gastrointestinal complications. Chan, F.K. Curr. Pharm. Des. (2003) [Pubmed]
  37. Relation of endotoxin, endotoxin binding proteins and macrophages to severe alcoholic liver injury and multiple organ failure. Fukui, H. Alcohol. Clin. Exp. Res. (2005) [Pubmed]
  38. The rationale for corticotropin-releasing hormone receptor (CRH-R) antagonists to treat depression and anxiety. Holsboer, F. Journal of psychiatric research. (1999) [Pubmed]
  39. Role of nitric oxide in implantation and menstruation. Chwalisz, K., Garfield, R.E. Hum. Reprod. (2000) [Pubmed]
  40. The mesolimbic dopamine system: the final common pathway for the reinforcing effect of drugs of abuse? Pierce, R.C., Kumaresan, V. Neuroscience and biobehavioral reviews. (2006) [Pubmed]
  41. Systematic review and meta-analysis of the efficacy of melatonin in experimental stroke. Macleod, M.R., O'Collins, T., Horky, L.L., Howells, D.W., Donnan, G.A. J. Pineal Res. (2005) [Pubmed]
  42. Does viloxazine have epileptogenic properties? Edwards, J.G., Glen-Bott, M. J. Neurol. Neurosurg. Psychiatr. (1984) [Pubmed]
  43. The black thyroid associated with minocycline therapy. A local manifestation of a drug-induced lysosome/substrate disorder. Reid, J.D. Am. J. Clin. Pathol. (1983) [Pubmed]
  44. Acetaldehyde, microbes, and cancer of the digestive tract. Salaspuro, M.P. Critical reviews in clinical laboratory sciences. (2003) [Pubmed]
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