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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Oct-3/4 repression accelerates differentiation of neural progenitor cells in vitro and in vivo.

Oct-3/4 (Oct-3/Oct-4/POU5F1) is a critical regulator of embryonic stem (ES) cell differentiation, though its role in tissue stem cells that persist in differentiated tissues has not been shown. Here, we show that Oct-3/4 is expressed in neurospheres (NS) composed of neural stem cells and neural progenitor cells and that up- or down-regulation of Oct-3/4 by using adenovirus vectors influences cell fate. Oct-3/4 down-regulation accelerates neuronal differentiation of progenitor cells while its sustained expression prevents neuronal differentiation. Transplantation of neurospheres into the adult rat brain shows that down-regulation of Oct-3/4 promotes differentiation of NS cells in vivo. Our findings indicate that Oct-3/4 is an essential regulator of NS cell differentiation and suggest that the modulation of Oct-3/4 could be a useful tool in clinical application of NS cells.[1]

References

  1. Oct-3/4 repression accelerates differentiation of neural progenitor cells in vitro and in vivo. Okuda, T., Tagawa, K., Qi, M.L., Hoshio, M., Ueda, H., Kawano, H., Kanazawa, I., Muramatsu, M., Okazawa, H. Brain Res. Mol. Brain Res. (2004) [Pubmed]
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