- Elevated urine pregnanetriolone definitively establishes the diagnosis of classical 21-hydroxylase deficiency in term and preterm neonates. Homma, K., Hasegawa, T., Takeshita, E., Watanabe, K., Anzo, M., Toyoura, T., Jinno, K., Ohashi, T., Hamajima, T., Takahashi, Y., Takahashi, T., Matsuo, N. J. Clin. Endocrinol. Metab. (2004)