The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

17-Hydroxyprogesterone     (8R,9S,10R,13S,14S,17R)-17- ethanoyl-17...

Synonyms: Setaderm, Gestageno, Prodix, Prodox, CHEMBL1062, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of 17-Hydroxyprogesterone


Psychiatry related information on 17-Hydroxyprogesterone


High impact information on 17-Hydroxyprogesterone


Chemical compound and disease context of 17-Hydroxyprogesterone


Biological context of 17-Hydroxyprogesterone


Anatomical context of 17-Hydroxyprogesterone


Associations of 17-Hydroxyprogesterone with other chemical compounds


Gene context of 17-Hydroxyprogesterone


Analytical, diagnostic and therapeutic context of 17-Hydroxyprogesterone


  1. Late-onset adrenal hyperplasia in hirsutism. Kuttenn, F., Couillin, P., Girard, F., Billaud, L., Vincens, M., Boucekkine, C., Thalabard, J.C., Maudelonde, T., Spritzer, P., Mowszowicz, I. N. Engl. J. Med. (1985) [Pubmed]
  2. Transplacental carcinogenesis (adrenocortical carcinoma) associated with hydroxyprogesterone hexanoate. Mann, J.R., Cameron, A.H., Gornall, P., Rayner, P.H., Shah, K.J. Lancet (1983) [Pubmed]
  3. Late-onset 21-hydroxylase deficiency mimicking idiopathic hirsutism or polycystic ovarian disease. Chrousos, G.P., Loriaux, D.L., Mann, D.L., Cutler, G.B. Ann. Intern. Med. (1982) [Pubmed]
  4. Development of a humanized disulfide-stabilized anti-p185HER2 Fv-beta-lactamase fusion protein for activation of a cephalosporin doxorubicin prodrug. Rodrigues, M.L., Presta, L.G., Kotts, C.E., Wirth, C., Mordenti, J., Osaka, G., Wong, W.L., Nuijens, A., Blackburn, B., Carter, P. Cancer Res. (1995) [Pubmed]
  5. Adrenocortical and gonadal steroids during sleep deprivation. Akerstedt, T., Palmblad, J., de la Torre, B., Marana, R., Gillberg, M. Sleep. (1980) [Pubmed]
  6. Androgen excess in cystic acne. Marynick, S.P., Chakmakjian, Z.H., McCaffree, D.L., Herndon, J.H. N. Engl. J. Med. (1983) [Pubmed]
  7. Extraadrenal steroid 21-hydroxylation is not mediated by P450c21. Mellon, S.H., Miller, W.L. J. Clin. Invest. (1989) [Pubmed]
  8. Isoleucine-15 of rainbow trout carbonyl reductase-like 20beta-hydroxysteroid dehydrogenase is critical for coenzyme (NADPH) binding. Guan, G., Todo, T., Tanaka, M., Young, G., Nagahama, Y. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  9. Immunocytochemical localization and biological activity of 3 beta-hydroxysteroid dehydrogenase in the central nervous system of the frog. Mensah-Nyagan, A.G., Feuilloley, M., Dupont, E., Do-Rego, J.L., Leboulenger, F., Pelletier, G., Vaudry, H. J. Neurosci. (1994) [Pubmed]
  10. CYP17 mutation E305G causes isolated 17,20-lyase deficiency by selectively altering substrate binding. Sherbet, D.P., Tiosano, D., Kwist, K.M., Hochberg, Z., Auchus, R.J. J. Biol. Chem. (2003) [Pubmed]
  11. Naturally occurring mutants of human steroid 21-hydroxylase (P450c21) pinpoint residues important for enzyme activity and stability. Nikoshkov, A., Lajic, S., Vlamis-Gardikas, A., Tranebjaerg, L., Holst, M., Wedell, A., Luthman, H. J. Biol. Chem. (1998) [Pubmed]
  12. Salivary and plasma androstenedione and 17-hydroxyprogesterone levels in congenital adrenal hyperplasia. Otten, B.J., Wellen, J.J., Rijken, J.C., Stoelinga, G.B., Benraad, T.J. J. Clin. Endocrinol. Metab. (1983) [Pubmed]
  13. Metformin effects on clinical features, endocrine and metabolic profiles, and insulin sensitivity in polycystic ovary syndrome: a randomized, double-blind, placebo-controlled 6-month trial, followed by open, long-term clinical evaluation. Moghetti, P., Castello, R., Negri, C., Tosi, F., Perrone, F., Caputo, M., Zanolin, E., Muggeo, M. J. Clin. Endocrinol. Metab. (2000) [Pubmed]
  14. Serum cortisol and 17-hydroxyprogesterone concentrations in children with classic congenital adrenal hyperplasia. Rosenfield, R.L. J. Clin. Endocrinol. Metab. (2002) [Pubmed]
  15. Impaired corpus luteum function in ectopic pregnancy cannot be explained by altered human chorionic gonadotropin. Norman, R.J., Buck, R.H., Kemp, M.A., Joubert, S.M. J. Clin. Endocrinol. Metab. (1988) [Pubmed]
  16. The activation of microsomal steroid 21-hydroxylase by cytosol from the cortex of bovine adrenals. Chasalow, F.I., Lieberman, S. J. Biol. Chem. (1979) [Pubmed]
  17. Phenotype-genotype correlation in 56 women with nonclassical congenital adrenal hyperplasia due to 21-hydroxylase deficiency. Deneux, C., Tardy, V., Dib, A., Mornet, E., Billaud, L., Charron, D., Morel, Y., Kuttenn, F. J. Clin. Endocrinol. Metab. (2001) [Pubmed]
  18. Prenatal diagnosis of 21-hydroxylase deficiency congenital adrenal hyperplasia by simultaneous radioimmunoassay of 21-deoxycortisol and 17-hydroxyprogesterone in amniotic fluid. Gueux, B., Fiet, J., Couillin, P., Raux-Demay, M.C., Mornet, E., Galons, H., Villette, J.M., Boue, J., Dreux, C. J. Clin. Endocrinol. Metab. (1988) [Pubmed]
  19. Fetal growth and the function of the adrenal cortex in preterm infants. Bolt, R.J., van Weissenbruch, M.M., Popp-Snijders, C., Sweep, C.G., Lafeber, H.N., Delemarre-van de Waal, H.A. J. Clin. Endocrinol. Metab. (2002) [Pubmed]
  20. A missense mutation at Ile172----Asn or Arg356----Trp causes steroid 21-hydroxylase deficiency. Chiou, S.H., Hu, M.C., Chung, B.C. J. Biol. Chem. (1990) [Pubmed]
  21. Identification of outer mitochondrial membrane cytochrome b5 as a modulator for androgen synthesis in Leydig cells. Ogishima, T., Kinoshita, J.Y., Mitani, F., Suematsu, M., Ito, A. J. Biol. Chem. (2003) [Pubmed]
  22. Augmented androgen production is a stable steroidogenic phenotype of propagated theca cells from polycystic ovaries. Nelson, V.L., Legro, R.S., Strauss, J.F., McAllister, J.M. Mol. Endocrinol. (1999) [Pubmed]
  23. Pitfalls of prenatal diagnosis of 21-hydroxylase deficiency congenital adrenal hyperplasia. Pang, S., Pollack, M.S., Loo, M., Green, O., Nussbaum, R., Clayton, G., Dupont, B., New, M.I. J. Clin. Endocrinol. Metab. (1985) [Pubmed]
  24. Congenital adrenal hyperplasia presenting as massive adrenal incidentalomas in the sixth decade of life: report of two patients with 21-hydroxylase deficiency. Ravichandran, R., Lafferty, F., McGinniss, M.J., Taylor, H.C. J. Clin. Endocrinol. Metab. (1996) [Pubmed]
  25. Steroidogenic enzyme activities, morphology, and receptor studies of a testicular adrenal rest in a patient with congenital adrenal hyperplasia. Clark, R.V., Albertson, B.D., Munabi, A., Cassorla, F., Aguilera, G., Warren, D.W., Sherins, R.J., Loriaux, D.L. J. Clin. Endocrinol. Metab. (1990) [Pubmed]
  26. Ovarian age-related responsiveness to human chorionic gonadotropin in women with polycystic ovary syndrome. Piltonen, T., Koivunen, R., Perheentupa, A., Morin-Papunen, L., Ruokonen, A., Tapanainen, J.S. J. Clin. Endocrinol. Metab. (2004) [Pubmed]
  27. Hormonal responses during various phases of autoimmune adrenal failure: no evidence for 21-hydroxylase enzyme activity inhibition in vivo. Boscaro, M., Betterle, C., Volpato, M., Fallo, F., Furmaniak, J., Rees Smith, B., Sonino, N. J. Clin. Endocrinol. Metab. (1996) [Pubmed]
  28. Ovarian 17-hydroxyprogesterone hyperresponsiveness to gonadotropin-releasing hormone (GnRH) agonist challenge in women with polycystic ovary syndrome is not mediated by luteinizing hormone hypersecretion: evidence from GnRH agonist and human chorionic gonadotropin stimulation testing. Ibañez, L., Hall, J.E., Potau, N., Carrascosa, A., Prat, N., Taylor, A.E. J. Clin. Endocrinol. Metab. (1996) [Pubmed]
  29. Attenuation of mild hyperandrogenic activity in postpubertal acne by a triphasic oral contraceptive containing low doses of ethynyl estradiol and d,l-norgestrel. Lemay, A., Dewailly, S.D., Grenier, R., Huard, J. J. Clin. Endocrinol. Metab. (1990) [Pubmed]
  30. Pituitary-adrenal responses to corticotropin-releasing factor in late onset 21-hydroxylase deficiency. Carmina, E., Lobo, R.A. Fertil. Steril. (1990) [Pubmed]
  31. CYP21 mutations and congenital adrenal hyperplasia. Lee, H. Clin. Genet. (2001) [Pubmed]
  32. Amplified and orderly growth hormone secretion characterizes lean adolescents with polycystic ovary syndrome. Garcia-Rudaz, M.C., Ropelato, M.G., Escobar, M.E., Veldhuis, J.D., Barontini, M. Eur. J. Endocrinol. (2002) [Pubmed]
  33. Effect of rosiglitazone on insulin resistance, growth factors, and reproductive disturbances in women with polycystic ovary syndrome. Belli, S.H., Graffigna, M.N., Oneto, A., Otero, P., Schurman, L., Levalle, O.A. Fertil. Steril. (2004) [Pubmed]
  34. Hormonal profiles in Italian late-onset adrenal hyperplasia correlate with HLA class III polymorphisms. Balsamo, A., Revelli, A., Borelli, I., Amoroso, A., Cenderelli, G., De Sanso, G., Mazzola, G., Curtoni, E.S., Zoppetti, G., Massobrio, M. Gynecol. Endocrinol. (1992) [Pubmed]
  35. A nonchromatographic radioimmunoassay for 17alpha-hydroxyprogesterone. Hami, M., Rosler, A., Rabinowitz, D. J. Clin. Endocrinol. Metab. (1975) [Pubmed]
  36. Genotyping is a valuable diagnostic complement to neonatal screening for congenital adrenal hyperplasia due to steroid 21-hydroxylase deficiency. Nordenström, A., Thilén, A., Hagenfeldt, L., Larsson, A., Wedell, A. J. Clin. Endocrinol. Metab. (1999) [Pubmed]
  37. Steroid profiling by tandem mass spectrometry improves the positive predictive value of newborn screening for congenital adrenal hyperplasia. Minutti, C.Z., Lacey, J.M., Magera, M.J., Hahn, S.H., McCann, M., Schulze, A., Cheillan, D., Dorche, C., Chace, D.H., Lymp, J.F., Zimmerman, D., Rinaldo, P., Matern, D. J. Clin. Endocrinol. Metab. (2004) [Pubmed]
  38. Specific factors predict the response to pulsatile gonadotropin-releasing hormone therapy in polycystic ovarian syndrome. Gill, S., Taylor, A.E., Martin, K.A., Welt, C.K., Adams, J.M., Hall, J.E. J. Clin. Endocrinol. Metab. (2001) [Pubmed]
WikiGenes - Universities