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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Exogenous luteinizing hormone in controlled ovarian hyperstimulation for assisted reproduction techniques.

OBJECTIVE: To investigate the role of exogenous LH in controlled ovarian hyperstimulation for assisted reproductive technologies. DESIGN: Prospective randomized study. SETTING: SISMER fertility unit. PATIENT(S): Women showing a hyporesponsiveness to FSH under GnRH agonist down-regulation were randomized into three groups: group A (n = 54) received an increased dosage of FSH; group B (n = 54) was administered recombinant LH in addition to the increased dose of FSH; group C (n = 22) was given additional FSH and LH using hMG as a combined drug. Fifty-four age-matched women with no need to increase the FSH dose were included as a control group (D). INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Implantation and live birth rate per started cycles. RESULT(S): In group B, the pregnancy and implantation rates were statistically higher when compared with groups A and C and did not differ from the control group for normal response. The live birth rate was similar in groups B and D but was half as high in groups A and C. CONCLUSION(S): Hyporesponsiveness to FSH could be related to iatrogenic LH deficiency that, in turn, could affect oocyte competence. Addition of a small amount of recombinant LH is able to rescue oocyte competence to produce viable embryos.[1]


  1. Exogenous luteinizing hormone in controlled ovarian hyperstimulation for assisted reproduction techniques. Ferraretti, A.P., Gianaroli, L., Magli, M.C., D'angelo, A., Farfalli, V., Montanaro, N. Fertil. Steril. (2004) [Pubmed]
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