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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Presurgical plasma exchange is ineffective in correcting amyloid associated factor X deficiency.

In patients with rare factor deficiencies, for which no factor concentrates are available, plasma exchange (PE) is an option for raising the desired factor level to approximately 80% for surgery. We report a case of acquired factor X ( FX) deficiency due to amyloidosis that required urgent surgical repair of an AV fistula aneurysm. This patient had a FX level of 3% at presentation; after 1.5 volume PE with fresh frozen plasma (FFP), his post-exchange FX was only 5%, indicating rapid adsorption of FX to amyloid fibrils. He was managed successfully with FEIBA during surgery.[1]

References

  1. Presurgical plasma exchange is ineffective in correcting amyloid associated factor X deficiency. Barker, B., Altuntas, F., Paranjape, G., Sarode, R. Journal of clinical apheresis. (2004) [Pubmed]
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