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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Proteomic analysis of human natural killer cells: insights on new potential NK immune functions.

Applying high-throughput proteomic analysis of mammalian cells can facilitate the identification of a large number of proteins expressed in the examined samples. Moreover, extensive research efforts are being made to perform large-scale characterization of membrane proteins. Here we use mass spectrometry-based proteomic strategy to characterize protein expression in membrane-enriched fractions derived from human NK lymphoma cell line YTS. This query yielded a list of over 1000 identified proteins, and provided us with new insights on NK cell biology. We highlight the expression of CD86 on YTS and its ability to co-stimulate TCR responses of human CD4+ T-cells, providing an unexpected link between innate and adaptive immune systems.[1]


  1. Proteomic analysis of human natural killer cells: insights on new potential NK immune functions. Hanna, J., Fitchett, J., Rowe, T., Daniels, M., Heller, M., Gonen-Gross, T., Manaster, E., Cho, S.Y., LaBarre, M.J., Mandelboim, O. Mol. Immunol. (2005) [Pubmed]
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