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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Antimycobacterial coumarins from the sardinian giant fennel (Ferula communis).

The structure of a new prenylated coumarin (E-omega-benzoyloxyferulenol, 1b) from the Sardinian giant fennel (Ferula communis) has been confirmed by synthesis. The parent compound ferulenol (1a) showed sub-micromolar antimycobacterial activity, which was partly retained in 1b and in the simplified synthetic analogue 3, but diminished in its omega-hydroxy and omega-acetoxy derivatives (1c and 1d, respectively). The outstanding activity of 1a, its low toxicity, and the evidence for definite structure-activity relationships make this prenylated 4-hydroxycoumarin an interesting antibacterial chemotype worth further investigation.[1]


  1. Antimycobacterial coumarins from the sardinian giant fennel (Ferula communis). Appendino, G., Mercalli, E., Fuzzati, N., Arnoldi, L., Stavri, M., Gibbons, S., Ballero, M., Maxia, A. J. Nat. Prod. (2004) [Pubmed]
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