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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Foeniculum


High impact information on Foeniculum

  • To test this stereochemical scheme, phosphatase-free preparations of (-)-endo-fenchol cyclase from fennel (Foeniculum vulgare M.) fruit were repeatedly incubated with a sample of (3RS)-[1-3H2]linalyl pyrophosphate until approximately 50% of this precursor was converted to the bicyclic monoterpenol end product [2].
  • Anethole, a chief constituent of anise, camphor, and fennel, has been shown to block both inflammation and carcinogenesis, but just how these effects are mediated is not known [3].
  • We tested sera of 15 patients who experienced adverse reactions to spiced food and characterized their IgE-binding patterns on anise, fennel, coriander and cumin extracts through immunoblot and inhibition experiments [4].
  • This paper demonstrates the special potential of vibrational NIR FT Raman microspectroscopy for the study of fennel fruits, chamomile inflorescence and curcuma roots to obtain detailed information about their microstructure and chemical composition [5].
  • Estragole (4-allyl-1-methoxybenzene) is a naturally occurring food flavoring agent found in basil, fennel, bay leaves, and other spices [6].

Chemical compound and disease context of Foeniculum

  • CONCLUSIONS: The essence of fennel can be used as a safe and effective herbal drug for primary dysmenorrhea, however, it may have a lower potency than mefenamic acid in the dosages used for this study [1].

Associations of Foeniculum with chemical compounds


Gene context of Foeniculum

  • Antioxidant and antimicrobial activity of Foeniculum vulgare and Crithmum maritimum essential oils [12].
  • Assuming that fifty percent reduction in seed yield and Na+/K+ ratio in leaf tissue as an index of alkali tolerance revealed that fennel was tolerant up to 25 ESP [13].
  • Antiinflammatory, analgesic and antioxidant activities of the fruit of Foeniculum vulgare [14].
  • Fennel and clove, spices known to add flavor and mask the fatty, fishy odor, activated glomeruli in the surrounding clusters and suppressed the alkylamine-induced and acid-aldehyde-induced responses of mitral cells, suggesting that the odor masking is mediated, in part, by lateral inhibitory connections in the odor maps of the olfactory bulb [15].

Analytical, diagnostic and therapeutic context of Foeniculum


  1. Comparison of fennel and mefenamic acid for the treatment of primary dysmenorrhea. Namavar Jahromi, B., Tartifizadeh, A., Khabnadideh, S. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics. (2003) [Pubmed]
  2. Biosynthesis of monoterpenes. Enantioselectivity in the enzymatic cyclization of linalyl pyrophosphate to (-)-endo-fenchol. Satterwhite, D.M., Wheeler, C.J., Croteau, R. J. Biol. Chem. (1985) [Pubmed]
  3. Anethole blocks both early and late cellular responses transduced by tumor necrosis factor: effect on NF-kappaB, AP-1, JNK, MAPKK and apoptosis. Chainy, G.B., Manna, S.K., Chaturvedi, M.M., Aggarwal, B.B. Oncogene (2000) [Pubmed]
  4. Characterization of allergens in Apiaceae spices: anise, fennel, coriander and cumin. Jensen-Jarolim, E., Leitner, A., Hirschwehr, R., Kraft, D., Wüthrich, B., Scheiner, O., Graf, J., Ebner, C. Clin. Exp. Allergy (1997) [Pubmed]
  5. Identification of secondary metabolites in medicinal and spice plants by NIR-FT-Raman microspectroscopic mapping. Baranska, M., Schulz, H., Rosch, P., Strehle, M.A., Popp, J. The Analyst. (2004) [Pubmed]
  6. Glucuronidation of 1'-hydroxyestragole (1'-HE) by human UDP-glucuronosyltransferases UGT2B7 and UGT1A9. Iyer, L.V., Ho, M.N., Shinn, W.M., Bradford, W.W., Tanga, M.J., Nath, S.S., Green, C.E. Toxicol. Sci. (2003) [Pubmed]
  7. Biosynthesis of monoterpenes: conversion of the acyclic precursors geranyl pyrophosphate and neryl pyrophosphate to the rearranged monoterpenes fenchol and fenchone by a soluble enzyme preparation from fennel (Foeniculum vulgare). Croteau, R., Felton, M., Ronald, R.C. Arch. Biochem. Biophys. (1980) [Pubmed]
  8. Potentiation of genotoxicity by concurrent application of compounds found in betel quid: arecoline, eugenol, quercetin, chlorogenic acid and Mn2+. Stich, H.F., Stich, W., Lam, P.P. Mutat. Res. (1981) [Pubmed]
  9. 2H/(1)H and (13)C/(12)C isotope ratios of trans-anethole using gas chromatography-isotope ratio mass spectrometry. Bilke, S., Mosandl, A. J. Agric. Food Chem. (2002) [Pubmed]
  10. Effect of oral administration of fennel (Foeniculum vulgare) on ciprofloxacin absorption and disposition in the rat. Zhu, M., Wong, P.Y., Li, R.C. J. Pharm. Pharmacol. (1999) [Pubmed]
  11. Volatile components and key odorants of fennel (Foeniculum vulgare Mill.) and thyme (Thymus vulgaris L.) oil extracts obtained by simultaneous distillation-extraction and supercritical fluid extraction. Díaz-Maroto, M.C., Díaz-Maroto Hidalgo, I.J., Sánchez-Palomo, E., Pérez-Coello, M.S. J. Agric. Food Chem. (2005) [Pubmed]
  12. Antioxidant and antimicrobial activity of Foeniculum vulgare and Crithmum maritimum essential oils. Ruberto, G., Baratta, M.T., Deans, S.G., Dorman, H.J. Planta Med. (2000) [Pubmed]
  13. Exchangeable sodium induced changes in yield, water relation and cation composition of fennel (Foeniculum vulgare Mill). Garg, V.K., Singh, P.K., Pushpangadan, P. Journal of environmental biology / Academy of Environmental Biology, India. (2005) [Pubmed]
  14. Antiinflammatory, analgesic and antioxidant activities of the fruit of Foeniculum vulgare. Choi, E.M., Hwang, J.K. Fitoterapia (2004) [Pubmed]
  15. Detection and masking of spoiled food smells by odor maps in the olfactory bulb. Takahashi, Y.K., Nagayama, S., Mori, K. J. Neurosci. (2004) [Pubmed]
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