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Kakigi, A. et al.

Kakigi, Takeda, Takeda, Sawada, Azuma, Higashiyama, Yamakawa, Takeuchi,

Time course of dehydrating effects of isosorbide on experimentally induced endolymphatic hydrops in guinea pigs.

Osmotic diuretics are therapeutic agents used to reduce endolymphatic hydrops. However, glycerol-induced change in endolymph volume is followed by a rebound phenomenon. In this study, we investigated the rebound phenomenon occurring with isosorbide, an osmotic diuretic used as a therapeutic agent for MÃ©niÃ¨re's disease in Japan. Forty guinea pigs underwent surgical obliteration of the endolymphatic sac. Thirty received isosorbide orally 1 month after surgery. These animals were sacrificed 3, 6, or 12 h after isosorbide intake. The remaining 10 animals served as controls. Quantitative assessment of changes in the endolymphatic space was performed light-microscopically. Isosorbide reduced cochlear endolymph volume, with a peak reduction 6 h after intake. Thereafter, no prominent rebound phenomenon was noted. Clinically, since isosorbide is orally administered every 8 h, rebound phenomenon need not be considered in the treatment with isosorbide.[1]

References

Time course of dehydrating effects of isosorbide on experimentally induced endolymphatic hydrops in guinea pigs. Kakigi, A., Takeda, S., Takeda, T., Sawada, S., Azuma, H., Higashiyama, K., Yamakawa, K., Takeuchi, S. ORL J. Otorhinolaryngol. Relat. Spec. (2004) [Pubmed]

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