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Chemical Compound Review

Isomannide     4,8- dioxabicyclo[3.3.0]octane- 2,6-diol

Synonyms: AGN-PC-00C9VC, SureCN244589, KST-1B7297, NSC-231906, NSC-270938, ...
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Disease relevance of isosorbide


Psychiatry related information on isosorbide


High impact information on isosorbide


Chemical compound and disease context of isosorbide


Biological context of isosorbide


Anatomical context of isosorbide

  • During arteriographically documented reocclusion, intracoronary isosorbide dinitrate (2 mg) reestablished the patency of the coronary artery within one to two minutes in 14 of 28 episodes that occurred in 11 of 16 patients [2].
  • BACKGROUND: Vaginal administration of the nitric oxide donor isosorbide mononitrate can induce effective ripening of the human cervix [23].
  • Angiograms of saphenous vein grafts (n = 11) or mammary artery grafts (n = 14) were obtained in basal conditions, after intravenous infusion of 0.4 mg methylergometrine, and after intragraft infusion of 1 mg isosorbide dinitrate [25].
  • Atrial natriuretic factor and isosorbide dinitrate modulate the gating of ATP-sensitive K+ channels in cultured vascular smooth muscle cells [26].
  • In order to determine some of the factors that could affect the individual response to this drug, we infused isosorbide dinitrate at a low dose (10 to 25 micrograms per kg per min) and a high dose (100 micrograms per kg per min) to rats with portal vein stenosis [27].

Associations of isosorbide with other chemical compounds


Gene context of isosorbide


Analytical, diagnostic and therapeutic context of isosorbide


  1. Effect of intervals between doses on the development of tolerance to isosorbide dinitrate. Parker, J.O., Farrell, B., Lahey, K.A., Moe, G. N. Engl. J. Med. (1987) [Pubmed]
  2. Intermittent coronary occlusion in acute myocardial infarction. Value of combined thrombolytic and vasodilator therapy. Hackett, D., Davies, G., Chierchia, S., Maseri, A. N. Engl. J. Med. (1987) [Pubmed]
  3. Prevention and reversal of nitrate tolerance in patients with congestive heart failure. Packer, M., Lee, W.H., Kessler, P.D., Gottlieb, S.S., Medina, N., Yushak, M. N. Engl. J. Med. (1987) [Pubmed]
  4. Hemicrania with oculosympathetic paresis from isosorbide dinitrate. Mueller, R.A., Meienberg, O. N. Engl. J. Med. (1983) [Pubmed]
  5. Nitrate therapy for congestive heart failure. Franciosa, J.A., Nordstrom, L.A., Cohn, J.N. JAMA (1978) [Pubmed]
  6. An open-label, multicenter, phase I/II study of single-agent AT-101 in men with castrate-resistant prostate cancer. Liu, G., Kelly, W.K., Wilding, G., Leopold, L., Brill, K., Somer, B. Clin. Cancer Res. (2009) [Pubmed]
  7. Effect of vasodilator therapy on mortality in chronic congestive heart failure. Results of a Veterans Administration Cooperative Study. Cohn, J.N., Archibald, D.G., Ziesche, S., Franciosa, J.A., Harston, W.E., Tristani, F.E., Dunkman, W.B., Jacobs, W., Francis, G.S., Flohr, K.H. N. Engl. J. Med. (1986) [Pubmed]
  8. Isosorbide 5-mononitrate: a review of a sustained-release formulation (Imdur) in stable angina pectoris. Gunasekara, N.S., Noble, S. Drugs (1999) [Pubmed]
  9. Visual hallucinations and suicidal ideation attributed to isosorbide dinitrate. Rosenthal, R. Psychosomatics. (1987) [Pubmed]
  10. Influence of emotional stress on pharmacokinetics of isosorbide dinitrate intraperitoneally administered to rats. Gomita, Y., Furuno, K., Araki, Y. Acta Med. Okayama (1990) [Pubmed]
  11. Topical treatment of erectile dysfunction: randomised double blind placebo controlled trial of cream containing aminophylline, isosorbide dinitrate, and co-dergocrine mesylate. Gomaa, A., Shalaby, M., Osman, M., Eissa, M., Eizat, A., Mahmoud, M., Mikhail, N. BMJ (1996) [Pubmed]
  12. Endoscopic ligation compared with combined treatment with nadolol and isosorbide mononitrate to prevent recurrent variceal bleeding. Villanueva, C., Miñana, J., Ortiz, J., Gallego, A., Soriano, G., Torras, X., Sáinz, S., Boadas, J., Cussó, X., Guarner, C., Balanzó, J. N. Engl. J. Med. (2001) [Pubmed]
  13. Evidence of impaired endothelium-dependent coronary vasodilatation in patients with angina pectoris and normal coronary angiograms. Egashira, K., Inou, T., Hirooka, Y., Yamada, A., Urabe, Y., Takeshita, A. N. Engl. J. Med. (1993) [Pubmed]
  14. Letter: Halitosis from isosorbide dinitrate. Bauman, D. JAMA (1975) [Pubmed]
  15. Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells. Garg, U.C., Hassid, A. J. Clin. Invest. (1989) [Pubmed]
  16. Isosorbide dinitrate and nifedipine treatment of achalasia: a clinical, manometric and radionuclide evaluation. Gelfond, M., Rozen, P., Gilat, T. Gastroenterology (1982) [Pubmed]
  17. Randomised trial of nadolol alone or with isosorbide mononitrate for primary prophylaxis of variceal bleeding in cirrhosis. Gruppo-Triveneto per L'ipertensione portale (GTIP). Merkel, C., Marin, R., Enzo, E., Donada, C., Cavallarin, G., Torboli, P., Amodio, P., Sebastianelli, G., Sacerdoti, D., Felder, M., Mazzaro, C., Beltrame, P., Gatta, A. Lancet (1996) [Pubmed]
  18. Efficacy of nifedipine and isosorbide mononitrate in combination with atenolol in stable angina. Akhras, F., Jackson, G. Lancet (1991) [Pubmed]
  19. Synergistic effect of prostaglandin E1 and isosorbide dinitrate in peripheral vascular disease. Sinzinger, H., Fitscha, P., O'Grady, J., Rauscha, F., Rogatti, W., Vane, J.R. Lancet (1990) [Pubmed]
  20. Combination vasodilator therapy for severe chronic congestive heart failure. Chatterjee, K., Drew, D., Parmley, W.W., Klausner, S.C., Polansky, J., Zacherle, B. Ann. Intern. Med. (1976) [Pubmed]
  21. Haemodynamic advantages of isosorbide dinitrate over frusemide in acute heart-failure following myocardial infarction. Nelson, G.I., Silke, B., Ahuja, R.C., Hussain, M., Taylor, S.H. Lancet (1983) [Pubmed]
  22. Hemodynamic evaluation of isosorbide dinitrate in alcoholic cirrhosis. Pharmacokinetic-hemodynamic interactions. Blei, A.T., Garcia-Tsao, G., Groszmann, R.J., Kahrilas, P., Ganger, D., Morse, S., Fung, H.L. Gastroenterology (1987) [Pubmed]
  23. Randomised trial of nitric oxide donor versus prostaglandin for cervical ripening before first-trimester termination of pregnancy. Thomson, A.J., Lunan, C.B., Ledingham, M., Howat, R.C., Cameron, I.T., Greer, I.A., Norman, J.E. Lancet (1998) [Pubmed]
  24. Treatment of nocturnal angina with 10 degrees reverse Trendelenburg bed position. Mohr, R., Smolinsky, A., Goor, D.A. Lancet (1982) [Pubmed]
  25. Vasomotor response to ergometrine and nitrates of saphenous vein grafts, internal mammary artery grafts, and grafted coronary arteries late after bypass surgery. Hanet, C., Robert, A., Wijns, W. Circulation (1992) [Pubmed]
  26. Atrial natriuretic factor and isosorbide dinitrate modulate the gating of ATP-sensitive K+ channels in cultured vascular smooth muscle cells. Kubo, M., Nakaya, Y., Matsuoka, S., Saito, K., Kuroda, Y. Circ. Res. (1994) [Pubmed]
  27. Isosorbide dinitrate in experimental portal hypertension: a study of factors that modulate the hemodynamic response. Blei, A.T., Gottstein, J. Hepatology (1986) [Pubmed]
  28. Nadolol plus isosorbide mononitrate compared with sclerotherapy for the prevention of variceal rebleeding. Villanueva, C., Balanzó, J., Novella, M.T., Soriano, G., Sáinz, S., Torras, X., Cussó, X., Guarner, C., Vilardell, F. N. Engl. J. Med. (1996) [Pubmed]
  29. Vasodilators and prostaglandin inhibitors in primary pulmonary hypertension. Hermiller, J.B., Bambach, D., Thompson, M.J., Huss, P., Fontana, M.E., Magorien, R.D., Unverferth, D.V., Leier, C.V. Ann. Intern. Med. (1982) [Pubmed]
  30. Comparison of low-dose aspirin and coronary vasodilators in acute unstable angina. Vejar, M., Hackett, D., Brunelli, C., Spallarossa, P., Ianetti, M., Galassi, A.R., Lipkin, D., Caponnetto, S., Patrono, C., Maseri, A. Circulation (1990) [Pubmed]
  31. Differential effects of captopril and nitrates on muscle sympathetic nerve activity in volunteers. Noll, G., Wenzel, R.R., de Marchi, S., Shaw, S., Lüscher, T.F. Circulation (1997) [Pubmed]
  32. Relative contributions of NOS isoforms during experimental colitis: endothelial-derived NOS maintains mucosal integrity. Vallance, B.A., Dijkstra, G., Qiu, B., van der Waaij, L.A., van Goor, H., Jansen, P.L., Mashimo, H., Collins, S.M. Am. J. Physiol. Gastrointest. Liver Physiol. (2004) [Pubmed]
  33. Organic nitrate tolerance is induced by degradation of some cytochrome P450 isoforms. Minamiyama, Y., Takemura, S., Nishino, Y., Okada, S. Redox Rep. (2002) [Pubmed]
  34. Heme oxygenase-1 induction may explain the antioxidant profile of pentaerythrityl trinitrate. Oberle, S., Abate, A., Grosser, N., Vreman, H.J., Dennery, P.A., Schneider, H.T., Stalleicken, D., Schröder, H. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  35. Susceptibility to cerulein-induced pancreatitis in inducible nitric oxide synthase-deficient mice. Qui, B., Mei, Q.B., Ma, J.J., Korsten, M.A. Pancreas (2001) [Pubmed]
  36. The human G-protein beta3 subunit C825T polymorphism is associated with coronary artery vasoconstriction. Meirhaeghe, A., Bauters, C., Helbecque, N., Hamon, M., McFadden, E., Lablanche, J.M., Bertrand, M., Amouyel, P. Eur. Heart J. (2001) [Pubmed]
  37. Banding ligation versus nadolol and isosorbide mononitrate for the prevention of esophageal variceal rebleeding. Lo, G.H., Chen, W.C., Chen, M.H., Hsu, P.I., Lin, C.K., Tsai, W.L., Lai, K.H. Gastroenterology (2002) [Pubmed]
  38. Effect of isosorbide and hydralazine in painful primary esophageal motility disorders. Mellow, M.H. Gastroenterology (1982) [Pubmed]
  39. Randomized, double-blind crossover study to investigate the effects of amlodipine and isosorbide mononitrate on the time course and severity of exercise-induced myocardial stunning. Rinaldi, C.A., Linka, A.Z., Masani, N.D., Avery, P.G., Jones, E., Saunders, H., Hall, R.J. Circulation (1998) [Pubmed]
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