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MeSH Review

Endolymphatic Sac

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Disease relevance of Endolymphatic Sac


High impact information on Endolymphatic Sac


Chemical compound and disease context of Endolymphatic Sac


Biological context of Endolymphatic Sac


Anatomical context of Endolymphatic Sac


Associations of Endolymphatic Sac with chemical compounds

  • The levels of AQP2 mRNA in the cochlea and endolymphatic sac were significantly higher in rats treated with vasopressin than the levels in control animals [24].
  • The exact contribution of the entire endolymphatic sac system to lactate buffering could not be determined in the present study [25].
  • The combined effects of glycerol and colchicine on the endolymphatic sac were investigated in mice [26].
  • Quantitative analysis of physiologic measurements from the endolymphatic sac requires knowledge of the anatomy of the structure, specifically the luminal volume and the variation of cross-sectional area with distance along the sac [27].
  • Within 15 min after administration of glycerol and urea the lumen of the endolymphatic sac was partially collapsed and the density of its contents was increased [28].

Gene context of Endolymphatic Sac


Analytical, diagnostic and therapeutic context of Endolymphatic Sac


  1. The endocrine system, vertigo and balance. Seemungal, B.M., Gresty, M.A., Bronstein, A.M. Curr. Opin. Neurol. (2001) [Pubmed]
  2. Endolymphatic sac tumor associated with a von Hippel-Lindau disease patient: an immunohistochemical study. Horiguchi, H., Sano, T., Toi, H., Kageji, T., Hirokawa, M., Nagahiro, S. Mod. Pathol. (2001) [Pubmed]
  3. Unusual lesions of the cerebellopontine angle: a segmental approach. Bonneville, F., Sarrazin, J.L., Marsot-Dupuch, K., Iffenecker, C., Cordoliani, Y.S., Doyon, D., Bonneville, J.F. Radiographics : a review publication of the Radiological Society of North America, Inc. (2001) [Pubmed]
  4. Intratympanic gentamicin therapy for persistent vertigo after endolymphatic sac surgery. Marzo, S.J., Leonetti, J.P. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery. (2002) [Pubmed]
  5. Modulation of the endolymphatic sac function. Takumida, M., Harada, Y., Bagger-Sjöbäck, D., Rask-Andersen, H. Acta oto-laryngologica. Supplementum. (1991) [Pubmed]
  6. Mutations in the gene encoding B1 subunit of H+-ATPase cause renal tubular acidosis with sensorineural deafness. Karet, F.E., Finberg, K.E., Nelson, R.D., Nayir, A., Mocan, H., Sanjad, S.A., Rodriguez-Soriano, J., Santos, F., Cremers, C.W., Di Pietro, A., Hoffbrand, B.I., Winiarski, J., Bakkaloglu, A., Ozen, S., Dusunsel, R., Goodyer, P., Hulton, S.A., Wu, D.K., Skvorak, A.B., Morton, C.C., Cunningham, M.J., Jha, V., Lifton, R.P. Nat. Genet. (1999) [Pubmed]
  7. Effects of VHL deficiency on endolymphatic duct and sac. Gläsker, S., Lonser, R.R., Tran, M.G., Ikejiri, B., Butman, J.A., Zeng, W., Maxwell, P.H., Zhuang, Z., Oldfield, E.H., Vortmeyer, A.O. Cancer Res. (2005) [Pubmed]
  8. Six1 controls patterning of the mouse otic vesicle. Ozaki, H., Nakamura, K., Funahashi, J., Ikeda, K., Yamada, G., Tokano, H., Okamura, H.O., Kitamura, K., Muto, S., Kotaki, H., Sudo, K., Horai, R., Iwakura, Y., Kawakami, K. Development (2004) [Pubmed]
  9. Dlx gene expression during chick inner ear development. Brown, S.T., Wang, J., Groves, A.K. J. Comp. Neurol. (2005) [Pubmed]
  10. Developmental and cellular expression pattern of epithelial sodium channel alpha, beta and gamma subunits in the inner ear of the rat. Gründer, S., Müller, A., Ruppersberg, J.P. Eur. J. Neurosci. (2001) [Pubmed]
  11. Correlations between serum osmolality and endolymphatic sac response using hypertonic glycerol. Jansson, B., Rask-Anderson, H. ORL J. Otorhinolaryngol. Relat. Spec. (1993) [Pubmed]
  12. Patients' subjective evaluations of quality of life related to disease-specific symptoms, sense of coherence, and treatment in Ménière's disease. Söderman, A.C., Bergenius, J., Bagger-Sjöbäck, D., Tjell, C., Langius, A. Otol. Neurotol. (2001) [Pubmed]
  13. Effect of urea on endolymphatic hydrops in guinea pigs. Yazawa, Y., Shea, J.J. ORL J. Otorhinolaryngol. Relat. Spec. (1985) [Pubmed]
  14. Histopathologic findings in Menière's disease. Wackym, P.A. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery. (1995) [Pubmed]
  15. Time course of dehydrating effects of isosorbide on experimentally induced endolymphatic hydrops in guinea pigs. Kakigi, A., Takeda, S., Takeda, T., Sawada, S., Azuma, H., Higashiyama, K., Yamakawa, K., Takeuchi, S. ORL J. Otorhinolaryngol. Relat. Spec. (2004) [Pubmed]
  16. The endolymphatic sac and inner ear homeostasis. II: Effect of glycerol on the sensory end organs with or without colchicine pretreatment. Takumida, M., Bagger-Sjöbäck, D., Rask-Andersen, H. Hear. Res. (1989) [Pubmed]
  17. Effects of acetazolamide on acid-base balance in the endolymphatic sac of the guinea pig. Tsujikawa, S., Yamashita, T., Tomoda, K., Iwai, H., Kumazawa, H., Cho, H., Kumazawa, T. Acta oto-laryngologica. Supplementum. (1993) [Pubmed]
  18. Calmodulin binding sites in the endolymphatic sac and stria vascularis of the human fetus and the guinea pig. Yamashita, H., Bagger-Sjöbäck, D. ORL J. Otorhinolaryngol. Relat. Spec. (1992) [Pubmed]
  19. VHL gene inactivation in an endolymphatic sac tumor associated with von Hippel-Lindau disease. Kawahara, N., Kume, H., Ueki, K., Mishima, K., Sasaki, T., Kirino, T. Neurology (1999) [Pubmed]
  20. Scanning electron microscopic and x-ray diffraction studies of otoconia in the lizard Podarcis s. sicula. Marmo, F., Franco, E., Balsamo, G. Cell Tissue Res. (1981) [Pubmed]
  21. Endocytotic activity of the free floating cells and epithelial cells in the endolymphatic sac: an electron microscopic study. Fukazawa, K., Sakagami, M., Matsunaga, T., Fujita, H. Anat. Rec. (1991) [Pubmed]
  22. Histologic and statistical studies on hyalin bodies in the human endolymphatic sac. Bui, H.T., Linthicum, F.H. The American journal of otology. (1989) [Pubmed]
  23. Proinflammatory cytokine expression in the endolymphatic sac during inner ear inflammation. Satoh, H., Firestein, G.S., Billings, P.B., Harris, J.P., Keithley, E.M. J. Assoc. Res. Otolaryngol. (2003) [Pubmed]
  24. Aquaporin-2 regulation by vasopressin in the rat inner ear. Sawada, S., Takeda, T., Kitano, H., Takeuchi, S., Kakigi, A., Azuma, H. Neuroreport (2002) [Pubmed]
  25. The role of mineralized tissue in the buffering of lactic acid during anoxia and exercise in the leopard frog Rana pipiens. Warren, D.E., Jackson, D.C. J. Exp. Biol. (2005) [Pubmed]
  26. The endolymphatic sac and inner ear homeostasis. I: Effect of glycerol on the endolymphatic sac with or without colchicine pretreatment. Takumida, M., Bagger-Sjöbäck, D., Rask-Andersen, H. Hear. Res. (1989) [Pubmed]
  27. Quantitative anatomy of the guinea pig endolymphatic sac. Pettit, K., Henson, M.M., Henson, O.W., Gewalt, S.L., Salt, A.N. Hear. Res. (2002) [Pubmed]
  28. General effects of hyperosmolar agents on the endolymphatic sac. Erwall, C. Hear. Res. (1988) [Pubmed]
  29. Expression of Delta1 and Serrate1 (Jagged1) in the mouse inner ear. Morrison, A., Hodgetts, C., Gossler, A., Hrabé de Angelis, M., Lewis, J. Mech. Dev. (1999) [Pubmed]
  30. Expression of carbonic anhydrase isoenzymes in the developing endolymphatic sac of the human fetus and the mouse embryo. Yamashita, H., Bagger-Sjöbäck, D., Sekitani, T. The Journal of laryngology and otology. (1992) [Pubmed]
  31. Coexpression of erythropoietin and its receptor in endolymphatic sac tumors. Vogel, T.W., Vortmeyer, A.O., Lubensky, I.A., Lee, Y.S., Furuta, M., Ikejiri, B., Kim, H.J., Lonser, R.R., Oldfield, E.H., Zhuang, Z. J. Neurosurg. (2005) [Pubmed]
  32. Expression pattern of aquaporin water channels in the inner ear of the rat. The molecular basis for a water regulation system in the endolymphatic sac. Beitz, E., Kumagami, H., Krippeit-Drews, P., Ruppersberg, J.P., Schultz, J.E. Hear. Res. (1999) [Pubmed]
  33. Subcellular changes in the endolymphatic sac after administration of hyperosmolar substances. Erwall, C., Jansson, B., Friberg, U., Rask-Andersen, H. Hear. Res. (1988) [Pubmed]
  34. Endolymphatic sac morphology following long-term kanamycin intoxication. Hultcrantz, M., Bagger-Sjöbäck, D. ORL J. Otorhinolaryngol. Relat. Spec. (1990) [Pubmed]
  35. Scanning electron microscopy and immunoglobulins of the endolymphatic sac in normal human subjects and sensorineural deafness. With special reference to Menière's disease. Kumagami, H. Acta oto-laryngologica. Supplementum. (1990) [Pubmed]
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