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Hall, A.J. et al.

Hall, Manesiotis, Emgenbroich, Quaglia, De Lorenzi, Sellergren,

Urea host monomers for stoichiometric molecular imprinting of oxyanions.

A series of urea-based vinyl monomers was synthesized and investigated for their ability to function as polymerizable hosts for the molecular imprinting of N-Z-D- or L-glutamic acid in polar media (DMSO or DMF). The monomers were synthesized in one step from a polymerizable isocyanate and a nonpolymerizable amine or vice versa, with yields typically over 70%. Prior to polymerization their solution binding properties vis-a-vis tetrabutylammonium benzoate in DMSO were investigated by 1H NMR, UV-vis and fluorescence monitored titrations. The affinities of the urea monomers for benzoate depended upon the substitution pattern of the urea, with all diaryl ureas exhibiting high affinity. EDMA-based imprinted polymers prepared in DMF or DMSO against Z-D-(or L)-glutamic acid using 2 equiv of the urea monomer and 2 equiv of base were able to recognize the imprinted dianion as well as larger molecules containing the glutamic acid substructure. The affinity, reflected in liquid chromatography retention data, correlated with the solution binding properties of the corresponding monomers.[1]

References

Urea host monomers for stoichiometric molecular imprinting of oxyanions. Hall, A.J., Manesiotis, P., Emgenbroich, M., Quaglia, M., De Lorenzi, E., Sellergren, B. J. Org. Chem. (2005) [Pubmed]

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