Role of 5-HT1A and 5-HT1B receptors in the hypophagic effect of 5-HT on the structure of feeding behavior.
BACKGROUND: Feeding behavior is deeply affected by serotonergic neurotransmission. This regulatory activity is mediated mainly by specific 5-HT1/2 receptors, and the paraventricular nucleus (PVN) plays a key role in this phenomena. In order to reveal the involvement of 5-HT1A and 5-HT1B receptors in the paraventricular nucleus of the hypothalamus (PVN) on serotonin-induced hypophagia, we examined the effects of intra-PVN injections of serotonin in WAY 100635 or SB 216641-pretreated rats on the structure of feeding behavior. MATERIAL/METHODS: Male Wistar rats were kept at 21+/-1 degrees C with a 12 h light /dark cycle on a self-selection feeding paradigm, provided with freely available and separate sources of protein, carbohydrate, fat and water. Blockade of 5-HT1A or 5-HT1B receptors in the paraventricular nucleus was effected by WAY 100635 (2 microg) or SB-216641 (2 microg) pretreatment; ten minutes later, 5-HT (2 microg) was applied into the same nucleus, then food intake and meal patterns were measured in a 30-minute period. The behavioral test was conducted at the beginning of the dark phase. RESULTS: The suppressive effect of 5-HT on carbohydrate intake was blocked by both WAY 100635 and SB 216641 at the beginning of the active (dark) feeding period. CONCLUSIONS: The hypophagic effect induced by 5-HT requires activation of 5-HT1A and 5-HT1B receptors, and the specific contribution of these subtype receptors is different, since the 5-HT1A subtype showed higher behavioral selectivity.[1]References
- Role of 5-HT1A and 5-HT1B receptors in the hypophagic effect of 5-HT on the structure of feeding behavior. Mancilla-Diaz, J.M., Escartin-Perez, R.E., Lopez-Alonso, V.E., Floran-Garduño, B., Romano-Camacho, J.B. Med. Sci. Monit. (2005) [Pubmed]
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