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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Ocular inflammation alters swelling and membrane characteristics of rat Müller glial cells.

Ocular inflammation is a common cause of retinal edema that may involve swelling of Müller glial cells. In order to investigate whether endotoxin-induced ocular inflammation in rats alters the swelling and membrane characteristics of Müller cells, lipopolysaccharide (LPS; 0.5%) was intravitreally injected. At 3 and 7 days after treatment, hypotonic challenge induced swelling of Müller cell somata that was not observed in non-treated control eyes. Müller cells of LPS-treated eyes displayed a downregulation of inward K(+) currents and upregulation of A-type K(+) currents that was associated with a decreased expression of Kir4.1 protein in retinal slices. The data suggest that ocular inflammation induces alterations of both the swelling characteristics and the K(+) channel expression of Müller cells.[1]

References

  1. Ocular inflammation alters swelling and membrane characteristics of rat Müller glial cells. Pannicke, T., Uckermann, O., Iandiev, I., Wiedemann, P., Reichenbach, A., Bringmann, A. J. Neuroimmunol. (2005) [Pubmed]
 
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