Disease relevance of Papilledema

• The most frequently observed neurologic signs were seizures, cranial nerve palsy, ataxia, papilledema, nystagmus, meningitis, tremor, rigidity, cortical blindness, and coma [1].
• Despite intensive plasma exchange, all patients developed neurologic signs (with seizures and coma in 2) and papilledema [2].
• CONCLUSIONS: These results demonstrate that INS37217 enhances subretinal fluid reabsorption in experimental retinal detachment in rabbits and support the development of INS37217 for stimulating subretinal fluid reabsorption in conditions that result in retinal detachment or retinal edema [3].
• Fluorescein angiography demonstrated impaired arteriolar flow, capillary non-perfusion, venous staining, retinal edema, and optic disc edema [4].
• The benefit of acetazolamide in IIH is questioned since weight loss, rather than acetazolamide, appeared to have been the catalyst for reducing the severity of papilledema [5].

Psychiatry related information on Papilledema

• Three patients were initially seen with headache, blurred vision, and papilledema while taking lithium carbonate for their respective bipolar affective disorder [6].

High impact information on Papilledema

• Nadolol and papilledema [7].
• IIHWOP was diagnosed if pressure was 200 mm CSF on two occasions and there was no papilledema [8].
• One recipient of rhIGF-I developed papilledema, which resolved spontaneously. rhIGF-I therapy did not alter serum IGF-binding protein-3 concentrations. rhIGF-I treatment is effective in stimulating skeletal growth in GH receptor deficiency [9].
• Visual disturbance due to retinal edema as a complication of imatinib [10].
• Localized hydrocortisone therapy may be developed as a treatment option for patients suffering from retinal edema due to diabetes [11].

Chemical compound and disease context of Papilledema

• The authors studied the therapeutic effect of acetazolamide on a patient with autosomal dominant retinitis pigmentosa complicated by retinal edema [12].
• Chronic papilledema may cause progressive visual loss and, for this reason, BIH is not a benign condition; fundal changes and visual function should be carefully monitored [13].
• RESULTS: In all three cases, papilledema resolved with the cessation of rhGH, and treatment with acetazolamide or prednisone [14].
• For a subgroup of patients with infection due to C. neoformans variety gattii, multiple enhancing lesions were observed on cerebral computed tomograms, and papilledema, high CSF and serum cryptococcal antigen titers, and a worse prognosis (despite prolonged amphotericin B therapy and intraventricular shunt insertion) were also noted [15].
• Patients with the highest baseline opening pressures (> or = 250 mm H2O) were distinguished by higher titers of cryptococcal capsular polysaccharide antigen in CSF; more frequently positive India ink smears of CSF; and more frequent headache, meningismus, papilledema, hearing loss, and pathological reflexes [16].

Biological context of Papilledema

• Increased intracranial pressure with papilledema persisted in the third patient when she failed to adjust psychiatrically, necessitating continuance of the lithium carbonate therapy [6].
• Twelve months after treatment, visual acuity improved by 3 or more lines in all patients, and decreased leakage of fluorescein from the CNV, as well as OCT evidence of reduced or resolved retinal edema, was seen at the last follow-up visit [17].
• Other effects of VEGF included prominent retinal vasodilation, vessel tortuousity, fluorescein leakage from retinal vessels, and inner retinal edema [18].
• A 40 year old chronic cocaine abuser came to hospital with a blood pressure of 260/160, headache, agitation and bilateral papilledema [19].

Anatomical context of Papilledema

• Fluorescein angiography revealed early leakage of the conjunctival capillaries and delayed filling of the lower retinal arterioles with retinal edema [20].
• Two had tight foramen magnum, one of which was associated with a cervical syrinx and markedly widened perioptic CSF spaces with papilledema [21].
• Three cases of papilledema secondary to chronic excessive vitamin A intake are presented, and the optic disk changes are documented with intravenous fluorescein angiography [22].
• BACKGROUND: In subtotal central retinal artery occlusion (CRAO), distinct retinal edema with acute onset irreversible visual loss is common. - METHODS: Clinical observation, fluorescein angiogram. - PATIENT: A 69-year-old patient presented with acute visual loss of his right eye [23].
• The Authors discuss the fluorescein angiographic pattern of 1) anterior ischemic optic neuropathy, 2) central retinal vein occlusion, 3) papilledema and 4) drusen [24].

Gene context of Papilledema

• The effectiveness of papilledema as an indicator of raised intracranial pressure in children with craniosynostosis [25].
• The most frequent presenting symptom was epilepsy (68%), and the most common sign was papilledema (85%) [26].
• In cases of severe HTN (with or without papilledema), the diagnosis of TTP should be held in abeyance until the effect of HTN control can be assessed [27].
• We report a patient with chronic, untreated idiopathic hypoparathyroidism who presented with papilledema and progressive deterioration of visual function [28].
• Typical and atypical Carney's triad presenting with malignant hypertension and papilledema [29].

Analytical, diagnostic and therapeutic context of Papilledema

• Cystoid macular edema and papilledema following cataract extraction: a fluorescein fundoscopic and angiographic study. 1966 [30].
• We present two patients, a 2 4/12-year-old girl with nephrotic syndrome, coma, papilledema, and hyperdensity along the sagittal sinus on CT; and a 34-year-old man with headaches, episodic visual loss, papilledema and a normal CT following posterior fossa craniotomy [31].

References