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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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IL-8 increases transmission of HIV type 1 in cervical explant tissue.

Interleukin-8 (IL-8) is the predominant cytokine expressed in the female genital tract of women with certain infectious/inflammatory conditions. IL-8 increased HIV-1 replication in T cells and to a greater extent in monocytes/macrophages in vitro. Physiological levels of IL-8 increased susceptibility to HIV-1 infection 5- to 8-fold in cervical explant tissues. Competitive inhibition of the IL-8 receptor CXCR2 with the small molecule inhibitor SB225002 resulted in a 45-70% decrease in cervical explant susceptibility to HIV-1 infection.[1]

References

  1. IL-8 increases transmission of HIV type 1 in cervical explant tissue. Narimatsu, R., Wolday, D., Patterson, B.K. AIDS Res. Hum. Retroviruses (2005) [Pubmed]
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