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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Liver phosphatases in mice treated with lead during murine ancylostomiasis.

Both infective larvae and pollutants disturb the homeostasis of female Swiss albino mice, causing ancylostomiasis and severe immunophysiological changes. In our experimental design, mice in group A were fed 0.01 mg of lead nitrate before infection with 500 larvae of Ancylostoma caninum, mice in group B were infected with larvae without previous lead treatment, and group C received lead nitrate treatment alone. Control animals in group D were neither treated with lead nitrate nor infected with larvae. While all three experimental groups showed disturbances in liver alkaline phosphatase ( ALP) and acid phosphatase ( ACP), group C receiving lead nitrate treatment alone and group A receiving lead nitrate with infection showed increased levels of ACP and decreased levels of ALP.[1]


  1. Liver phosphatases in mice treated with lead during murine ancylostomiasis. Satyalatha, B.D., Vardhani, V.V. Ecotoxicol. Environ. Saf. (2005) [Pubmed]
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