The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

CID6327084     lead; nitric acid

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of AIDS-004145


High impact information on AIDS-004145


Chemical compound and disease context of AIDS-004145


Biological context of AIDS-004145


Anatomical context of AIDS-004145


Associations of AIDS-004145 with other chemical compounds

  • Pretreatment of rats with a single dose of dexamethasone (2 mg/kg) 60 minutes before lead nitrate (100 mumol/kg) or ethylene dibromide completely abolished the increased levels of liver TNF-alpha mRNA induced by these agents [22].
  • Transient inhibition by orotic acid does not abolish the in vivo response of rat hepatocytes to a direct mitogen, lead nitrate [23].
  • While the rats were on these regimens they were given liver cell proliferative stimulus, either a compensatory type (two-thirds partial hepatectomy or a necrogenic dose of carbon tetrachloride) or a direct hyperplastic stimulus such as that induced by the primary mitogen, lead nitrate [24].
  • Both insoluble lead sulfide and more soluble lead nitrate were mutagenic at the HPRT locus in V79 cells [25].
  • A maximal decrease in PEMT activity (60%) and loss of PEMT2 protein (95%) coincided with maximal DNA synthesis and maximal cytidine triphosphate:phosphocholine cytidylyltransferase activity 36 h and 48 h after lead nitrate stimulation in male and female livers respectively [26].

Gene context of AIDS-004145


Analytical, diagnostic and therapeutic context of AIDS-004145


  1. Liver cell proliferation induced by nafenopin and cyproterone acetate is not associated with increases in activation of transcription factors NF-kappaB and AP-1 or with expression of tumor necrosis factor alpha. Menegazzi, M., Carcereri-De Prati, A., Suzuki, H., Shinozuka, H., Pibiri, M., Piga, R., Columbano, A., Ledda-Columbano, G.M. Hepatology (1997) [Pubmed]
  2. Occurrence of cell death (apoptosis) during the involution of liver hyperplasia. Columbano, A., Ledda-Columbano, G.M., Coni, P.P., Faa, G., Liguori, C., Santa Cruz, G., Pani, P. Lab. Invest. (1985) [Pubmed]
  3. Teratogenicity, fetal toxicity, and placental transfer of lead nitrate in rats. McClain, R.M., Becker, B.A. Toxicol. Appl. Pharmacol. (1975) [Pubmed]
  4. Lead nitrate-induced development of hypercholesterolemia in rats: sterol-independent gene regulation of hepatic enzymes responsible for cholesterol homeostasis. Kojima, M., Masui, T., Nemoto, K., Degawa, M. Toxicol. Lett. (2004) [Pubmed]
  5. Chemical and ultrastructural examination of lead-induced morphological convertants of Bacillus subtilis. Barrow, W., Tornabene, T.G. Chem. Biol. Interact. (1979) [Pubmed]
  6. Hepatocyte proliferation induced in rats by lead nitrate is suppressed by several tumor necrosis factor alpha inhibitors. Kubo, Y., Yasunaga, M., Masuhara, M., Terai, S., Nakamura, T., Okita, K. Hepatology (1996) [Pubmed]
  7. Immunoelectron microscopy identification of early proliferating cells in rat liver tissue during hyperplasia induced by lead nitrate. Rijhsinghani, K., Choi, H.S., Burton, L.A., Paronetto, F., Tavoloni, N. Hepatology (1993) [Pubmed]
  8. Hepatocyte proliferation induced by a single dose of a peroxisome proliferator. Ohmura, T., Ledda-Columbano, G.M., Piga, R., Columbano, A., Glemba, J., Katyal, S.L., Locker, J., Shinozuka, H. Am. J. Pathol. (1996) [Pubmed]
  9. Direct hyperplasia does not enhance the kinetics of liver repopulation in a new model of hepatocyte transplantation in the rat. Pani, P., Laconi, S., Pillai, S., Scintu, F., Curreli, F., Shafritz, D.A., Laconi, E. J. Hepatol. (1999) [Pubmed]
  10. Protective role of zeolite on short- and long-term lead toxicity in the teleost fish Heteropneustes fossilis. Jain, S.K. Chemosphere (1999) [Pubmed]
  11. Brain stem GABA receptor functional regulation during rat liver cell proliferation. Biju, M.P., Pyroja, S., Rajeshkumar, N.V., Paulose, C.S. Neurochem. Res. (2002) [Pubmed]
  12. Effects of lead(II) nitrate and a dithiocarbamate fungicide on the rat lung. Adamis, Z., Tátrai, E., Honma, K., Ungváry, G. Journal of applied toxicology : JAT. (1999) [Pubmed]
  13. Fatal Clostridium botulinum toxicosis in eleven Holstein cattle fed round bale barley haylage. Kelch, W.J., Kerr, L.A., Pringle, J.K., Rohrbach, B.W., Whitlock, R.H. J. Vet. Diagn. Invest. (2000) [Pubmed]
  14. Lead and liver cell proliferation. Effect of repeated administrations. Ledda-Columbano, G.M., Columbano, A., Pani, P. Am. J. Pathol. (1983) [Pubmed]
  15. Effects of cell proliferation and cell death (apoptosis and necrosis) on the early stages of rat hepatocarcinogenesis. Columbano, A., Endoh, T., Denda, A., Noguchi, O., Nakae, D., Hasegawa, K., Ledda-Columbano, G.M., Zedda, A.I., Konishi, Y. Carcinogenesis (1996) [Pubmed]
  16. Effect of lead nitrate on liver carbohydrate enzymes and glycogen content in the rat. Hacker, H.J., Bannasch, P., Columbano, A. Carcinogenesis (1990) [Pubmed]
  17. CYP76C2, an Arabidopsis thaliana cytochrome P450 gene expressed during hypersensitive and developmental cell death. Godiard, L., Sauviac, L., Dalbin, N., Liaubet, L., Callard, D., Czernic, P., Marco, Y. FEBS Lett. (1998) [Pubmed]
  18. Possible roles of nonparenchymal cells in hepatocyte proliferation induced by lead nitrate and by tumor necrosis factor alpha. Shinozuka, H., Ohmura, T., Katyal, S.L., Zedda, A.I., Ledda-Columbano, G.M., Columbano, A. Hepatology (1996) [Pubmed]
  19. Effect of various concentrations of lead nitrate on the induction of micronuclei in mouse bone marrow. Jagetia, G.C., Aruna, R. Mutat. Res. (1998) [Pubmed]
  20. Activity of alkaline phosphatase in rat skeletal muscle localized along the sarcolemma and endothelial cell membranes. Safadi, A., Livne, E., Silbermann, M., Reznick, A.Z. J. Histochem. Cytochem. (1991) [Pubmed]
  21. Genotoxicity of inorganic lead salts and disturbance of microtubule function. Bonacker, D., Stoiber, T., Böhm, K.J., Prots, I., Wang, M., Unger, E., Thier, R., Bolt, H.M., Degen, G.H. Environ. Mol. Mutagen. (2005) [Pubmed]
  22. Dexamethasone inhibits induction of liver tumor necrosis factor-alpha mRNA and liver growth induced by lead nitrate and ethylene dibromide. Ledda-Columbano, G.M., Columbano, A., Cannas, A., Simbula, G., Okita, K., Kayano, K., Kubo, Y., Katyal, S.L., Shinozuka, H. Am. J. Pathol. (1994) [Pubmed]
  23. Transient inhibition by orotic acid does not abolish the in vivo response of rat hepatocytes to a direct mitogen, lead nitrate. Laconi, E., Yusuf, A., Jahangir, A.R., Laconi, S., Rao, P.M., Rajalakshmi, S., Sanna, F., Pani, P., Monni, A., Sarma, D.S. J. Hepatol. (1997) [Pubmed]
  24. Mitogen-induced liver hyperplasia does not substitute for compensatory regeneration during promotion of chemical hepatocarcinogenesis. Ledda-Columbano, G.M., Coni, P., Curto, M., Giacomini, L., Faa, G., Sarma, D.S., Columbano, A. Carcinogenesis (1992) [Pubmed]
  25. Genetic toxicology of lead compounds. Zelikoff, J.T., Li, J.H., Hartwig, A., Wang, X.W., Costa, M., Rossman, T.G. Carcinogenesis (1988) [Pubmed]
  26. Transient inactivation of phosphatidylethanolamine N-methyltransferase-2 and activation of cytidine triphosphate: phosphocholine cytidylyltransferase during non-neoplastic liver growth. Tessitore, L., Cui, Z., Vance, D.E. Biochem. J. (1997) [Pubmed]
  27. Roles of growth factors and of tumor necrosis factor-alpha on liver cell proliferation induced in rats by lead nitrate. Shinozuka, H., Kubo, Y., Katyal, S.L., Coni, P., Ledda-Columbano, G.M., Columbano, A., Nakamura, T. Lab. Invest. (1994) [Pubmed]
  28. Tumor necrosis factor-alpha-independent downregulation of hepatic cholesterol 7alpha-hydroxylase gene in mice treated with lead nitrate. Kojima, M., Sekikawa, K., Nemoto, K., Degawa, M. Toxicol. Sci. (2005) [Pubmed]
  29. Gene expression of neurotrophins and their receptors in lead nitrate-induced rat liver hyperplasia. Nemoto, K., Miyata, S., Nemoto, F., Yasumoto, T., Murai, U., Kageyama, H., Degawa, M. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  30. Ploidy and nuclearity of rat hepatocytes after compensatory regeneration or mitogen-induced liver growth. Melchiorri, C., Chieco, P., Zedda, A.I., Coni, P., Ledda-Columbano, G.M., Columbano, A. Carcinogenesis (1993) [Pubmed]
  31. Demonstration of acid phosphatase-containing vacuoles in hyphal tip cells of Sclerotium rolfsii. Hänssler, G., Maxwell, D.P., Maxwell, M.D. J. Bacteriol. (1975) [Pubmed]
WikiGenes - Universities