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MeSH Review


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Disease relevance of Ancylostoma


High impact information on Ancylostoma


Biological context of Ancylostoma


Anatomical context of Ancylostoma

  • Intestinal extracts from normal [uninfected] and experimental [infected with a repeated dose of 500 + 500 + 1000 Ancylostoma caninum larvae] mice were bioassayed for histamine using isolated guinea pig ileum preparation [14].
  • The alterations of mast cell counts induced in the gut of swiss albino mice by infection with Ancylostoma caninum larvae have been studied, both in single and multiple infections [15].
  • The number of peripheral eosinophils was counted in female Swiss albino mice on 1, 4, 9, 16 and 30 days after infection with various single (500, 1000 and 2000) and weekly repeated (500 + + 500 + 1000, 1000 + 1000 and 1000 + 1000 + 2000) doses of filariform Ancylostoma caninum larvae [16].

Associations of Ancylostoma with chemical compounds

  • We expressed a catalytically active cysteine protease, Ac-CP-2, from the blood-feeding stage of the canine hookworm Ancylostoma caninum and vaccinated dogs with the purified protease [17].
  • Zoonotic hookworm larvae of the genus Ancylostoma were shown to contain a hyaluronidase activity that migrated on modified sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) hyaluronic acid gels with an apparent Mr of 49,000 [18].
  • Role of reactive oxygen species in the chemoprophylactic action of methyl [5-[[4-(2-pyridinyl)-1-piperazinyl]-carbonyl]-1H-benzimidazol-2 yl] carbamate in hamster against Ancylostoma ceylanicum [19].
  • NADH oxidase and fumarate reductase of Ancylostoma ceylanicum [20].
  • Antibody against adult Ancylostoma caninum excretory-secretory (ES) products was used to immunoscreen a cDNA expression library leading to the isolation of cDNAs encoding putative hookworm fatty-acid and retinol-binding proteins [21].

Gene context of Ancylostoma


Analytical, diagnostic and therapeutic context of Ancylostoma


  1. Anthelmintics. Katz, M. Drugs (1977) [Pubmed]
  2. Efficacy of ivermectin and pyrantel pamoate combined in a chewable formulation against heartworm, hookworm, and ascarid infections in dogs. Clark, J.N., Daurio, C.P., Plue, R.E., Wallace, D.H., Longhofer, S.L. Am. J. Vet. Res. (1992) [Pubmed]
  3. Efficacy of fenbendazole against giardiasis in dogs. Barr, S.C., Bowman, D.D., Heller, R.L. Am. J. Vet. Res. (1994) [Pubmed]
  4. In vivo expression of neutrophil inhibitory factor via gene transfer prevents lipopolysaccharide-induced lung neutrophil infiltration and injury by a beta2 integrin-dependent mechanism. Zhou, M.Y., Lo, S.K., Bergenfeldt, M., Tiruppathi, C., Jaffe, A., Xu, N., Malik, A.B. J. Clin. Invest. (1998) [Pubmed]
  5. Hookworm: developmental biology of the infectious process. Hawdon, J.M., Hotez, P.J. Curr. Opin. Genet. Dev. (1996) [Pubmed]
  6. beta(2)-Integrin blockade driven by E-selectin promoter prevents neutrophil sequestration and lung injury in mice. Xu, N., Rahman, A., Minshall, R.D., Tiruppathi, C., Malik, A.B. Circ. Res. (2000) [Pubmed]
  7. A broad spectrum Kunitz type serine protease inhibitor secreted by the hookworm Ancylostoma ceylanicum. Milstone, A.M., Harrison, L.M., Bungiro, R.D., Kuzmic, P., Cappello, M. J. Biol. Chem. (2000) [Pubmed]
  8. Evolution of glycoprotein hormone subunit genes in bilateral metazoa: identification of two novel human glycoprotein hormone subunit family genes, GPA2 and GPB5. Hsu, S.Y., Nakabayashi, K., Bhalla, A. Mol. Endocrinol. (2002) [Pubmed]
  9. Ancylostoma caninum anticoagulant peptide blocks metastasis in vivo and inhibits factor Xa binding to melanoma cells in vitro. Donnelly, K.M., Bromberg, M.E., Milstone, A., Madison McNiff, J.M., Terwilliger, G., Konigsberg, W.H., Cappello, M. Thromb. Haemost. (1998) [Pubmed]
  10. Ac-SAA-1, an immunodominant 16 kDa surface-associated antigen of infective larvae and adults of Ancylostoma caninum. Zhan, B., Wang, Y., Liu, Y., Williamson, A., Loukas, A., Hawdon, J.M., Xue, H.C., Xiao, S.H., Hotez, P.J. Int. J. Parasitol. (2004) [Pubmed]
  11. The influence of thyroxine on the host-parasite relationship of Ancylostoma caninum in Swiss albino mice. Bhai, I., Pandey, A.K. Int. J. Parasitol. (1981) [Pubmed]
  12. Isolation and molecular cloning of a secreted hookworm platelet inhibitor from adult Ancylostoma caninum. Del Valle, A., Jones, B.F., Harrison, L.M., Chadderdon, R.C., Cappello, M. Mol. Biochem. Parasitol. (2003) [Pubmed]
  13. Genetic markers in ribosomal DNA for hookworm identification. Gasser, R.B., Stewart, L.E., Speare, R. Acta Trop. (1996) [Pubmed]
  14. Pharmacological estimation of histamine in the intestine of mice experimentally infected with repeated doses of Ancylostoma caninum larvae. Varhani, V., Johri, G.N. Journal of hygiene, epidemiology, microbiology, and immunology. (1981) [Pubmed]
  15. Intestinal mast cells during experimental ancylostomiasis. Vardhani, V., Johri, G.N. J. Helminthol. (1979) [Pubmed]
  16. Ancylostoma caninum: a report on the peripheral eosinophilia in naive and immunized Swiss albino mice. Kolhe, N.P., Johri, G.N. Folia Parasitol. (1983) [Pubmed]
  17. Vaccination of dogs with a recombinant cysteine protease from the intestine of canine hookworms diminishes the fecundity and growth of worms. Loukas, A., Bethony, J.M., Williamson, A.L., Goud, G.N., Mendez, S., Zhan, B., Hawdon, J.M., Elena Bottazzi, M., Brindley, P.J., Hotez, P.J. J. Infect. Dis. (2004) [Pubmed]
  18. Hyaluronidase from infective Ancylostoma hookworm larvae and its possible function as a virulence factor in tissue invasion and in cutaneous larva migrans. Hotez, P.J., Narasimhan, S., Haggerty, J., Milstone, L., Bhopale, V., Schad, G.A., Richards, F.F. Infect. Immun. (1992) [Pubmed]
  19. Role of reactive oxygen species in the chemoprophylactic action of methyl [5-[[4-(2-pyridinyl)-1-piperazinyl]-carbonyl]-1H-benzimidazol-2 yl] carbamate in hamster against Ancylostoma ceylanicum. Singh, S.P., Srivastava, J.K., Katiyar, J.C., Srivastava, V.M. Biochem. Pharmacol. (1994) [Pubmed]
  20. NADH oxidase and fumarate reductase of Ancylostoma ceylanicum. Goyal, N., Gupta, S., Katiyar, J.C., Srivastava, V.M. Int. J. Parasitol. (1991) [Pubmed]
  21. Ac-FAR-1, a 20 kDa fatty acid- and retinol-binding protein secreted by adult Ancylostoma caninum hookworms: gene transcription pattern, ligand binding properties and structural characterisation. Basavaraju, S., Zhan, B., Kennedy, M.W., Liu, Y., Hawdon, J., Hotez, P.J. Mol. Biochem. Parasitol. (2003) [Pubmed]
  22. Molecular approaches to vaccinating against hookworm disease. Hotez, P.J., Hawdon, J.M., Cappello, M., Jones, B.F., Ghosh, K., Volvovitz, F., Xiao, S.H. Pediatr. Res. (1996) [Pubmed]
  23. Vaccination with neutrophil inhibitory factor reduces the fecundity of the hookworm Ancylostoma ceylanicum. Ali, F., Brown, A., Stanssens, P., Timothy, L.M., Soule, H.R., Pritchard, D.I. Parasite Immunol. (2001) [Pubmed]
  24. Ancylostoma caninum MTP-1, an astacin-like metalloprotease secreted by infective hookworm larvae, is involved in tissue migration. Williamson, A.L., Lustigman, S., Oksov, Y., Deumic, V., Plieskatt, J., Mendez, S., Zhan, B., Bottazzi, M.E., Hotez, P.J., Loukas, A. Infect. Immun. (2006) [Pubmed]
  25. In vitro expression of a recombinant paramyosin of Ancylostoma caninum. Kohlmetz, C., Epe, C., Schnieder, T. Int. J. Parasitol. (1998) [Pubmed]
  26. Molecular analysis of astacin-like metalloproteases of Ostertagia ostertagi. De Maere, V., Vercauteren, I., Geldhof, P., Gevaert, K., Vercruysse, J., Claerebout, E. Parasitology (2005) [Pubmed]
  27. An immunological and biochemical comparison of hookworm species. Pritchard, D.I., McKean, P.G., Schad, G.A. Parasitol. Today (Regul. Ed.) (1990) [Pubmed]
  28. Molecular cloning and characterization of Ac-mep-1, a developmentally regulated gut luminal metalloendopeptidase from adult Ancylostoma caninum hookworms. Jones, B.F., Hotez, P.J. Mol. Biochem. Parasitol. (2002) [Pubmed]
  29. Tribendimidine: a promising, safe and broad-spectrum anthelmintic agent from China. Xiao, S.H., Hui-Ming, W., Tanner, M., Utzinger, J., Chong, W. Acta Trop. (2005) [Pubmed]
  30. Anthelmintic activity of closantel against Ancylostoma caninum in dogs. Guerrero, J., Page, M.R., Schad, G.A. J. Parasitol. (1982) [Pubmed]
  31. Amplification and characterization of cysteine proteinase genes from nematodes. Harrop, S.A., Prociv, P., Brindley, P.J. Trop. Med. Parasitol. (1995) [Pubmed]
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