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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Osteoblastic proliferative activity of Epimedium brevicornum Maxim.

The effect of the extracts of Epimedium brevicornum Maxim. was investigated on proliferative activity in vitro. The osteoblast-like UMR106 cells was employed as an osteoblast model. The EtOH extract and the n-butanol fraction from the crude extract were found to show proliferation stimulating activity. Three flavonoid compounds (icariin, epimedin B and epimedin C) were isolated from this fraction by activity-guided assay, and the effects on cell proliferation were studied. Icariin produced the most significant promoting effect on the proliferation in osteoblast-like UMR106 cells. The results suggested that E. brevicornum Maxim. extracts might have potential activity against osteoporosis, and flavonoids such as icariin might be the active constituents stimulating osteoblasts.[1]


  1. Osteoblastic proliferative activity of Epimedium brevicornum Maxim. Meng, F.H., Li, Y.B., Xiong, Z.L., Jiang, Z.M., Li, F.M. Phytomedicine (2005) [Pubmed]
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