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Chemical Compound Review

Icariin     5-hydroxy-2-(4- methoxyphenyl)-8-(3...

Synonyms: Ieariline, AC1NSXJE, SureCN312615, Bio-0292, BSPBio_002599, ...
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Disease relevance of Icariin


Psychiatry related information on Icariin


High impact information on Icariin

  • This fact reveals that, by the view of kinetics, icariin is an antioxidant with much higher effectiveness [6].
  • Results showed p53 to be an important regulator in the differentiation in embryonic stem cells treated with 10(-7) M icariin, controlling or adjusting the balance between differentiated cells and cells undergoing apoptosis [7].
  • A marked increase in apoptosis rate was observed 48 h after icariin treatment [7].
  • The aim of this study was to investigate the possible inducible effects and to clarify the modulation by icariin of cell cycle and p53 expression in the differentiation of embryonic stem cells into cardiomyocytes in vitro [7].
  • Flow cytometry revealed that 10(-7) M icariin treatment for 48 h significantly induced the accumulation of cells in G0/G1 and reduced the proportion of cells in S phase [7].

Biological context of Icariin


Anatomical context of Icariin

  • In conclusion, icariin at 10(-7) M facilitated the directional differentiation of embryonic stem cells into cardiomyocytes [7].
  • The antihepatotoxic activity of icariin was also estimated by the determination of total cytochrome P-450 content and glutathione-S-transferase activity in the CCl4-intoxicated hepatocytes [1].
  • The antioxidative effect of icariin in human erythrocytes against free-radical-induced haemolysis [11].
  • Icariin was able to enhance cGMP levels in SNP-treated cavernous smooth muscle cells [12].
  • The results suggested that E. brevicornum Maxim. extracts might have potential activity against osteoporosis, and flavonoids such as icariin might be the active constituents stimulating osteoblasts [13].

Associations of Icariin with other chemical compounds


Gene context of Icariin

  • RESULTS: Icariin significantly elevated mRNA levels of cardiac transcription factors GATA4 and Nkx2.5, and cardiac-specific alpha-MHC, MLC-2v and beta-AR genes in a concentration- and time-dependent manner (P<0.05) [10].
  • The experimental results demonstrate that icariin, isolated from Herba epimedii, was a strong agonist for NMU2R, which could selectively activate NMU2R, but not M1R, MC4R, and negative cell lines [14].
  • Effects of icariin on cGMP-specific PDE5 and cAMP-specific PDE4 activities [5].
  • The inhibitory effects of icariin on PDE5 and PDE4 activities were investigated by the two-step radioisotope procedure with [(3)H]-cGMP/[(3)H]-cAMP [5].
  • (2) Icariin treatment also improved the steady-state serum BGP and might have promoted bone formation [15].

Analytical, diagnostic and therapeutic context of Icariin


  1. Antihepatotoxic activity of icariin, a major constituent of Epimedium koreanum. Lee, M.K., Choi, Y.J., Sung, S.H., Shin, D.I., Kim, J.W., Kim, Y.C. Planta Med. (1995) [Pubmed]
  2. Cytotoxic effects of Coptis chinensis and Epimedium sagittatum extracts and their major constituents (berberine, coptisine and icariin) on hepatoma and leukaemia cell growth. Lin, C.C., Ng, L.T., Hsu, F.F., Shieh, D.E., Chiang, L.C. Clin. Exp. Pharmacol. Physiol. (2004) [Pubmed]
  3. Protective effects of icariin on neurons injured by cerebral ischemia/reperfusion. Li, L., Zhou, Q.X., Shi, J.S. Chin. Med. J. (2005) [Pubmed]
  4. Estrogenic effects of two derivatives of icariin on human breast cancer MCF-7 cells. Ye, H.Y., Lou, Y.J. Phytomedicine (2005) [Pubmed]
  5. Effects of icariin on cGMP-specific PDE5 and cAMP-specific PDE4 activities. Xin, Z.C., Kim, E.K., Lin, C.S., Liu, W.J., Tian, L., Yuan, Y.M., Fu, J. Asian J. Androl. (2003) [Pubmed]
  6. Icariin: a special antioxidant to protect linoleic acid against free-radical-induced peroxidation in micelles. Liu, Z.Q. The journal of physical chemistry. A, Molecules, spectroscopy, kinetics, environment & general theory. (2006) [Pubmed]
  7. Icariin-mediated modulation of cell cycle and p53 during cardiomyocyte differentiation in embryonic stem cells. Zhu, D., Qu, L., Zhang, X., Lou, Y. Eur. J. Pharmacol. (2005) [Pubmed]
  8. Effects of Icariin on expression of OPN mRNA and type I collagen in rat osteoblasts in vitro. Xiao, Q., Chen, A., Guo, F. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. (2005) [Pubmed]
  9. Effect of icariin on cyclic GMP levels and on the mRNA expression of cGMP-binding cGMP-specific phosphodiesterase (PDE5) in penile cavernosum. Jiang, Z., Hu, B., Wang, J., Tang, Q., Tan, Y., Xiang, J., Liu, J. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban (2006) [Pubmed]
  10. Icariin-mediated expression of cardiac genes and modulation of nitric oxide signaling pathway during differentiation of mouse embryonic stem cells into cardiomyocytes in vitro. Zhu, D.Y., Lou, Y.J. Acta Pharmacol. Sin. (2006) [Pubmed]
  11. The antioxidative effect of icariin in human erythrocytes against free-radical-induced haemolysis. Liu, Z.Q., Luo, X.Y., Sun, Y.X., Wu, W., Liu, C.M., Liu, Z.Q., Liu, S.Y. J. Pharm. Pharmacol. (2004) [Pubmed]
  12. Effects of icariin on phosphodiesterase-5 activity in vitro and cyclic guanosine monophosphate level in cavernous smooth muscle cells. Ning, H., Xin, Z.C., Lin, G., Banie, L., Lue, T.F., Lin, C.S. Urology (2006) [Pubmed]
  13. Osteoblastic proliferative activity of Epimedium brevicornum Maxim. Meng, F.H., Li, Y.B., Xiong, Z.L., Jiang, Z.M., Li, F.M. Phytomedicine (2005) [Pubmed]
  14. Screening of active compounds as neuromedin U2 receptor agonist from natural products. Zheng, X., Hu, Y., Liu, J., Ouyang, K. Bioorg. Med. Chem. Lett. (2005) [Pubmed]
  15. The testosterone mimetic properties of icariin. Zhang, Z.B., Yang, Q.T. Asian J. Androl. (2006) [Pubmed]
  16. Determination of icariin in Chinese traditional medicine by capillary zone electrophoresis. Chai, Y., Ji, S., Zhang, G., Wu, Y., Yin, X., Liang, D., Xu, Z. Biomed. Chromatogr. (1999) [Pubmed]
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