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MeSH Review:

Epimedium

Zhang, X. et al., De Naeyer, A. et al., Sun, J.L. et al., Liu, J.J. et al., Li, W.K. et al., et al.

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High impact information on Epimedium

A capillary zone electrophoresis (CZE) separation were developed for simultaneous determination of four flavonoids including icariin, epimedin A, epimedin B and epimedin C in Epimedium [1].
Two compound Chinese herbal medicinal ingredients (cCIs) were prepared respectively with epimedium polysaccharide (EPS) plus propolis flavone (PF) and astragalus polysaccharide (APS) plus ginsenoside (GS) [2].
Icariin, icaritin and desmethylicaritin are constituents of Epimedium with a similar structure to genistein and daidzein [3].
Purification of icariin from the extract of Epimedium segittatum using high-speed counter-current chromatography [4].
Flavonol glycosides from Epimedium sagittatum and their neurite outgrowth activity on PC12h cells [5].

Biological context of Epimedium

The in vivo investigation demonstrated that both the epimedium and estradiol were able to increase mineral content and promote bone formation [6].

Associations of Epimedium with chemical compounds

Isolation and immunomodulatory effect of flavonol glycosides from Epimedium hunanense [7].
The present data suggested that Epimedium extract could inhibit the activity of AdoHcy hydrolase, thus regulating the cellular biomethylation as well as reducing cellular Hcy level [8].
Anhydroicaritin 3-O-rhamnosyl(1-->2)rhamnoside from epimedium koreanum and a reappraisal of other rhamnosyl(1-->2, 1-->3 and 1-->4)rhamnoside structures [9].
In the present paper, the inhibitory effect of Epimedium extract on the activity of S-adenosyl-L-homocysteine (AdoHcy) Hydrolase was studied [8].
A novel flavonol glycoside named caohuoside-B was isolated from the aerial parts of Epimedium koreanum, along with a known flavonol glycoside, epimedokoreanoside-I [10].

Gene context of Epimedium

Inhibitory effect of Epimedium extract on S-adenosyl-L-homocysteine hydrolase and biomethylation [8].

Analytical, diagnostic and therapeutic context of Epimedium

The estrogenic activity of a polyphenolic extract of the leaves of Epimedium brevicornum and five fractions obtained by solid-phase extraction were investigated using estrogen-responsive bioassays, a yeast cell assay and the Ishikawa Var-I assay [11].

References

Optimization for quantitative determination of four flavonoids in Epimedium by capillary zone electrophoresis coupled with diode array detection using central composite design. Liu, J.J., Li, S.P., Wang, Y.T. Journal of chromatography. A. (2006) [Pubmed]
Immunologic enhancement of compound Chinese herbal medicinal ingredients and their efficacy comparison with compound Chinese herbal medicines. Sun, J.L., Hu, Y.L., Wang, D.Y., Zhang, B.K., Liu, J.G. Vaccine (2006) [Pubmed]
Proliferation-stimulating effects of icaritin and desmethylicaritin in MCF-7 cells. Wang, Z.Q., Lou, Y.J. Eur. J. Pharmacol. (2004) [Pubmed]
Purification of icariin from the extract of Epimedium segittatum using high-speed counter-current chromatography. Du, Q., Xia, M., Ito, Y. Journal of chromatography. A. (2002) [Pubmed]
Flavonol glycosides from Epimedium sagittatum and their neurite outgrowth activity on PC12h cells. Kuroda, M., Mimaki, Y., Sashida, Y., Umegaki, E., Yamazaki, M., Chiba, K., Mohri, T., Kitahara, M., Yasuda, A., Naoi, N., Xu, Z.W., Li, M.R. Planta Med. (2000) [Pubmed]
In vitro and in vivo studies of the effect of a Chinese herb medicine on osteoclastic bone resorption. Yu, S., Chen, K., Li, S., Zhang, K. The Chinese journal of dental research : the official journal of the Scientific Section of the Chinese Stomatological Association (CSA). (1999) [Pubmed]
Isolation and immunomodulatory effect of flavonol glycosides from Epimedium hunanense. Liang, H.R., Vuorela, P., Vuorela, H., Hiltunen, R. Planta Med. (1997) [Pubmed]
Inhibitory effect of Epimedium extract on S-adenosyl-L-homocysteine hydrolase and biomethylation. Zhang, X., Li, Y., Yang, X., Wang, K., Ni, J., Qu, X. Life Sci. (2005) [Pubmed]
Anhydroicaritin 3-O-rhamnosyl(1-->2)rhamnoside from epimedium koreanum and a reappraisal of other rhamnosyl(1-->2, 1-->3 and 1-->4)rhamnoside structures. Li, W.K., Pan, J.Q., Lü, M.J., Xiao, P.G., Zhang, R.Y. Phytochemistry (1996) [Pubmed]
Flavonol glycosides from Epimedium koreanum. Li, W.K., Xiao, P.G., Tu, G.Z., Ma, L.B., Zhang, R.Y. Phytochemistry (1995) [Pubmed]
Estrogenic activity of a polyphenolic extract of the leaves of Epimedium brevicornum. De Naeyer, A., Pocock, V., Milligan, S., De Keukeleire, D. Fitoterapia (2005) [Pubmed]

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