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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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RNA interference: a mammalian SID-1 homologue enhances siRNA uptake and gene silencing efficacy in human cells.

SID-1 is a transmembrane protein that mediates systemic RNA interference in Caenorhabditis elegans. Here we show that the mammalian SID-1 homologue FLJ20174 localizes to the cell membrane of human cells and enhances their uptake of small interfering RNA (siRNA), resulting in increased siRNA-mediated gene silencing efficacy. This is the first demonstration to show that overexpression of a membrane protein enhances siRNA internalization in mammalian cells. This observation raises the possibility of enhancing the efficacy of RNA interference.[1]

References

  1. RNA interference: a mammalian SID-1 homologue enhances siRNA uptake and gene silencing efficacy in human cells. Duxbury, M.S., Ashley, S.W., Whang, E.E. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
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