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Gene Review

SIDT1  -  SID1 transmembrane family, member 1

Homo sapiens

Synonyms: B830021E24Rik, FLJ20174, SID-1, SID1, SID1 transmembrane family member 1
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Disease relevance of SIDT1

  • Hepatitis C virus core protein represses p21WAF1/Cip1/Sid1 promoter activity [1].

Psychiatry related information on SIDT1

  • To assess predictions from social identity development theory (SIDT; Nesdale, 2004) concerning children's ethnic/racial prejudice, 197 Anglo-Australian children ages 7 or 9 years participated in a minimal group study as a member of a team that had a norm of inclusion or exclusion [2].

High impact information on SIDT1

  • Here, we report that p400 is a component of the p53-p21(WAF1/CIP1/sid1) pathway, regulating the p21 transcription and senescence induction program [3].
  • P21(Waf1/Cip1/Sid1) is a critical component of biomolecular pathways leading to the G(1) arrest evoked in response to DNA damage, growth arrest signals and differentiation commitment [4].
  • RNA interference: a mammalian SID-1 homologue enhances siRNA uptake and gene silencing efficacy in human cells [5].
  • SID-1 is a transmembrane protein that mediates systemic RNA interference in Caenorhabditis elegans [5].
  • The protective effects of the HCV core protein on ceramide-induced cell death were reflected by the reduced expression of p21(WAF1/Cip1/Sid1) and the sustained expression of the Bcl-2 protein in the HCV core-expressing cells with respect to the vector-transfected cells [6].

Anatomical context of SIDT1

  • Here we show that the mammalian SID-1 homologue FLJ20174 localizes to the cell membrane of human cells and enhances their uptake of small interfering RNA (siRNA), resulting in increased siRNA-mediated gene silencing efficacy [5].


  1. Hepatitis C virus core protein represses p21WAF1/Cip1/Sid1 promoter activity. Ray, R.B., Steele, R., Meyer, K., Ray, R. Gene (1998) [Pubmed]
  2. Group norms, threat, and children's racial prejudice. Nesdale, D., Maass, A., Durkin, K., Griffiths, J. Child development. (2005) [Pubmed]
  3. The p400 E1A-associated protein is a novel component of the p53 --> p21 senescence pathway. Chan, H.M., Narita, M., Lowe, S.W., Livingston, D.M. Genes Dev. (2005) [Pubmed]
  4. Expression of P21(WAF1/CIP1/SID1) cyclin-dependent kinase inhibitor in hematopoietic progenitor cells. Campanini, F., Santucci, M.A., Brusa, G., Pattacini, L., Arpinati, M., Rondelli, D., Gamberi, B., Barbieri, E., Babini, L., Tura, S. Gene (2001) [Pubmed]
  5. RNA interference: a mammalian SID-1 homologue enhances siRNA uptake and gene silencing efficacy in human cells. Duxbury, M.S., Ashley, S.W., Whang, E.E. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  6. Suppression of ceramide-induced cell death by hepatitis C virus core protein. Kim, J.S., Ryu, J., Hwang, S.B., Lee, S.Y., Choi, S.Y., Park, J. J. Biochem. Mol. Biol. (2004) [Pubmed]
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