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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

CXCL16 is a novel angiogenic factor for human umbilical vein endothelial cells.

CXCL16 is a unique chemokine with characteristics as a receptor for phosphatidylserine and oxidized low density lipoproteins in macrophages, and is involved in the accumulation of cellular cholesterol during atherosclerotic lesion development. In this study, we report a new function of CXCL16 as a novel angiogenic factor in human umbilical vein endothelial cells (HUVEC). CXCL16 stimulated proliferation and chemotaxis of HUVEC in a dose-dependent manner, reaching a maximum at 1 nM. CXCL16 also significantly induced tube formation of HUVEC on Matrigel. Further, exposure of HUVEC to CXCL16 led to a time- and dose-dependent activation of mitogen-activated protein kinase (ERK1/2), which was completely inhibited by a mitogen-activated protein kinase kinase inhibitor, PD98059. Proliferation and tube formation in response to CXCL16 were also blocked by the pretreatment with PD98059, but not CXCL16-induced chemotaxis. Thus, our data indicate that CXCL16 may act as a novel angiogenic factor for HUVEC and that ERK is involved as an important signaling molecule to mediate its angiogenic effects.[1]


  1. CXCL16 is a novel angiogenic factor for human umbilical vein endothelial cells. Zhuge, X., Murayama, T., Arai, H., Yamauchi, R., Tanaka, M., Shimaoka, T., Yonehara, S., Kume, N., Yokode, M., Kita, T. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
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