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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

SEC18/NSF-independent, protein-sorting pathway from the yeast cortical ER to the plasma membrane.

Classic studies of temperature-sensitive secretory (sec) mutants have demonstrated that secreted and plasma membrane proteins follow a common SEC pathway via the endoplasmic reticulum (ER), Golgi apparatus, and secretory vesicles to the cell periphery. The yeast protein Ist2p, which is synthesized from a localized mRNA, travels from the ER to the plasma membrane via a novel route that operates independently of the formation of coat protein complex II-coated vesicles. In this study, we show that the COOH-terminal domain of Ist2p is necessary and sufficient to mediate SEC18-independent sorting when it is positioned at the COOH terminus of different integral membrane proteins and exposed to the cytoplasm. This domain functions as a dominant plasma membrane localization determinant that overrides other protein sorting signals. Based on these observations, we suggest a local synthesis of Ist2p at cortical ER sites, from where the protein is sorted by a novel mechanism to the plasma membrane.[1]


  1. SEC18/NSF-independent, protein-sorting pathway from the yeast cortical ER to the plasma membrane. Jüschke, C., Wächter, A., Schwappach, B., Seedorf, M. J. Cell Biol. (2005) [Pubmed]
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