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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

RhoB regulates endosome transport by promoting actin assembly on endosomal membranes through Dia1.

Rho GTPases are crucial regulators of the actin cytoskeleton and they play a role in the control of membrane trafficking. In contrast to the close family members RhoA and RhoC, RhoB localises to endosomes and delays epidermal growth factor receptor traffic. Here, we show that activated RhoB induces the peripheral distribution of endosomes, which align along subcortical actin stress fibres and are surrounded by an actin coat. The Diaphanous-related formin, Dia1, is recruited to endosomes by activated RhoB. Dia1 is required for the formation of the actin coat around endosomes downstream of RhoB, connecting membrane trafficking with the regulation of actin dynamics.[1]

References

  1. RhoB regulates endosome transport by promoting actin assembly on endosomal membranes through Dia1. Fernandez-Borja, M., Janssen, L., Verwoerd, D., Hordijk, P., Neefjes, J. J. Cell. Sci. (2005) [Pubmed]
 
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