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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

New insights into regulation of the tryptophan biosynthetic operon in Gram-positive bacteria.

The tryptophan operon of Bacillus subtilis serves as an excellent model for investigating transcription regulation in Gram-positive bacteria. In this article, we extend this knowledge by analyzing the predicted regulatory regions in the trp operons of other fully sequenced Gram-positive bacteria. Interestingly, it appears that in eight of the organisms examined, transcription of the trp operon appears to be regulated by tandem T-box elements. These regulatory elements have recently been described in the trp operons of two bacterial species. Single T-box elements are commonly found in Gram-positive bacteria in operons encoding aminoacyl tRNA synthetases and proteins performing other functions. Different regulatory mechanisms appear to be associated with variations of trp gene organization within the trp operon.[1]


  1. New insights into regulation of the tryptophan biosynthetic operon in Gram-positive bacteria. Gutierrez-Preciado, A., Jensen, R.A., Yanofsky, C., Merino, E. Trends Genet. (2005) [Pubmed]
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