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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Seladin-1/DHCR24 expression in normal ovary, ovarian epithelial and granulosa tumours.

OBJECTIVE: The human DIMINUTO/DWARF1 homolog seladin-1/DHCR24 has been recently reported to be up-regulated in adrenocortical adenomas. Seladin-1 expression has been reported in the normal ovary. Granulosa cell tumours of the ovary ( GCT) as with adrenocortical adenomas arise from a steroidogenic tissue, respond to pituitary hormone stimulation and synthesize steroid hormones. DESIGN: To test the hypothesis that seladin-1 may also have a role in the pathogenesis of GCT, we determined the expression of seladin-1 in a cohort of GCT and in mucinous and serous cystadenocarcinomas and in normal ovary. MEASUREMENTS: Expression was determined by RT-PCR using gene specific primers and probes combined with Southern blot analysis of the PCR products. RESULTS: Seladin-1 expression was identified in the normal ovary, mucinous cystadenocarcinomas and serous cystadenocarcinomas of the ovary whereas no expression was observed in the GCT. CONCLUSIONS: Based on our results, seladin-1 is not expressed in the granulosa cells or at least not in those that give rise to GCT.[1]


  1. Seladin-1/DHCR24 expression in normal ovary, ovarian epithelial and granulosa tumours. Fuller, P.J., Alexiadis, M., Jobling, T., McNeilage, J. Clin. Endocrinol. (Oxf) (2005) [Pubmed]
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