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Weng, H.R. et al.

Weng, Aravindan, Cata, Chen, Shaw, Dougherty,

Spinal glial glutamate transporters downregulate in rats with taxol-induced hyperalgesia.

Changes in the expression of glial glutamate transporters (GLAST and GLT-1) were examined in the spinal cord of rats with chemotherapy (taxol)-induced mechanical hyperalgesia. Immunohistochemical studies show that the expression of both GLAST and GLT-1 in the L4-L5 spinal dorsal horn is decreased by 24% (P<0.001) and 23% (P<0.001), respectively, in rats with taxol-induced hyperalgesia as compared with those in control rats. These changes were further confirmed using an enzyme-linked immunosorbent assay that confirmed downregulation of GLAST by 36% (P<0.05) and GLT-1 by 18% (P<0.05) in the L4-L5 spinal cord of taxol-treated rats. These data indicate that downregulation of glutamate transporters may contribute to the development of hyperalgesia induced by taxol and suggest that glutamate transporters may be a new target for treatment of pain.[1]

References

Spinal glial glutamate transporters downregulate in rats with taxol-induced hyperalgesia. Weng, H.R., Aravindan, N., Cata, J.P., Chen, J.H., Shaw, A.D., Dougherty, P.M. Neurosci. Lett. (2005) [Pubmed]

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