- Human splicing factor SPF45 (RBM17) confers broad multidrug resistance to anticancer drugs when overexpressed--a phenotype partially reversed by selective estrogen receptor modulators. Perry, W.L., Shepard, R.L., Sampath, J., Yaden, B., Chin, W.W., Iversen, P.W., Jin, S., Lesoon, A., O'Brien, K.A., Peek, V.L., Rolfe, M., Shyjan, A., Tighe, M., Williamson, M., Krishnan, V., Moore, R.E., Dantzig, A.H. Cancer Res. (2005)