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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

A common pathway for genetic events leading to pheochromocytoma.

Mutations in VHL, RET, NF1, SDHB, SDHC, and SDHD can give rise to pheochromocytoma/paraganglioma. These different genetic lesions may all act by decreasing the activity of a 2-oxoglutarate-dependent oxygenase, SM-20/EglN3/PHD3, resulting in reduced apoptosis of neural crest cells during development.[1]


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