Gene Review:
EGLN1 - egl-9 family hypoxia-inducible factor 1
Homo sapiens
Synonyms:
C1orf12, ECYT3, Egl nine homolog 1, HALAH, HIF-PH2, ...
Pouysségur,
Berra,
Olmos,
Castellanos,
Volmat,
Landazuri,
Wenger,
Xu,
Mekel,
Kato,
Roux,
Sheville,
Kawamoto,
Warshakoon,
Wu,
Wolf,
Matsuda,
del Peso,
Walter,
Inoue,
Marxsen,
Wirthner,
Martin-Puig,
Nishimura,
Cuevas,
Spielmann,
Camenisch,
Hellwig-Bürgel,
Renock,
Stiehl,
Köditz,
Stiehl,
Metzen,
Doege,
Ginouvès,
Pokross,
Benizri,
Evdokimov,
Boyer,
Melanie J. Percy,
Paul W. Furlow,
Philip A. Beer,
Terence R. J. Lappin,
Mary Frances McMullin,
Frank S. Lee,
Asanoma,
Wake,
Taylor,
Jelkmann,
Temes,
- The von Hippel Lindau/hypoxia-inducible factor (HIF) pathway regulates the transcription of the HIF-proline hydroxylase genes in response to low oxygen. del Peso, L., Castellanos, M.C., Temes, E., Martin-Puig, S., Cuevas, Y., Olmos, G., Landazuri, M.O. J. Biol. Chem. (2003)
- Induction of human endometrial cancer cell senescence through modulation of HIF-1alpha activity by EGLN1. Kato, H., Inoue, T., Asanoma, K., Nishimura, C., Matsuda, T., Wake, N. Int. J. Cancer (2006)
- Characterization and comparative analysis of the EGLN gene family. Taylor, M.S. Gene (2001)
- Overexpression and nuclear translocation of hypoxia-inducible factor prolyl hydroxylase PHD2 in head and neck squamous cell carcinoma is associated with tumor aggressiveness. Jokilehto, T., Rantanen, K., Luukkaa, M., Heikkinen, P., Grenman, R., Minn, H., Kronqvist, P., Jaakkola, P.M. Clin. Cancer Res. (2006)
- A novel erythrocytosis-associated PHD2 mutation suggests the location of a HIF binding groove. Percy, M.J., Furlow, P.W., Beer, P.A., Lappin, T.R., McMullin, M.F., Lee, F.S. Blood (2007)
- The von Hippel-Lindau tumor suppressor protein: new insights into oxygen sensing and cancer. Kim, W., Kaelin, W.G. Curr. Opin. Genet. Dev. (2003)
- HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia. Berra, E., Benizri, E., Ginouvès, A., Volmat, V., Roux, D., Pouysségur, J. EMBO J. (2003)
- Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2). McDonough, M.A., Li, V., Flashman, E., Chowdhury, R., Mohr, C., Liénard, B.M., Zondlo, J., Oldham, N.J., Clifton, I.J., Lewis, J., McNeill, L.A., Kurzeja, R.J., Hewitson, K.S., Yang, E., Jordan, S., Syed, R.S., Schofield, C.J. Proc. Natl. Acad. Sci. U.S.A. (2006)
- Suppression of hypoxia-inducible factor 1alpha (HIF-1alpha) transcriptional activity by the HIF prolyl hydroxylase EGLN1. To, K.K., Huang, L.E. J. Biol. Chem. (2005)
- Dynamic HIF1A regulation during human placental development. Ietta, F., Wu, Y., Winter, J., Xu, J., Wang, J., Post, M., Caniggia, I. Biol. Reprod. (2006)
- Hypoxia-inducible Factors in the First Trimester Human Lung. Groenman, F., Rutter, M., Caniggia, I., Tibboel, D., Post, M. J. Histochem. Cytochem. (2007)
- Hypoxia-inducible factor-1 (HIF-1) promotes its degradation by induction of HIF-alpha-prolyl-4-hydroxylases. Marxsen, J.H., Stengel, P., Doege, K., Heikkinen, P., Jokilehto, T., Wagner, T., Jelkmann, W., Jaakkola, P., Metzen, E. Biochem. J. (2004)
- Gene expression profiling of parkinsonian substantia nigra pars compacta; alterations in ubiquitin-proteasome, heat shock protein, iron and oxidative stress regulated proteins, cell adhesion/cellular matrix and vesicle trafficking genes. Grünblatt, E., Mandel, S., Jacob-Hirsch, J., Zeligson, S., Amariglo, N., Rechavi, G., Li, J., Ravid, R., Roggendorf, W., Riederer, P., Youdim, M.B. Journal of neural transmission (Vienna, Austria : 1996) (2004)
- A novel series of imidazo[1,2-a]pyridine derivatives as HIF-1alpha prolyl hydroxylase inhibitors. Warshakoon, N.C., Wu, S., Boyer, A., Kawamoto, R., Sheville, J., Renock, S., Xu, K., Pokross, M., Evdokimov, A.G., Walter, R., Mekel, M. Bioorg. Med. Chem. Lett. (2006)
- The polybasic region that follows the plant homeodomain zinc finger 1 of pf1 is necessary and sufficient for specific phosphoinositide binding. Kaadige, M.R., Ayer, D.E. J. Biol. Chem. (2006)
- Inhibition of the catalytic activity of hypoxia-inducible factor-1alpha-prolyl-hydroxylase 2 by a MYND-type zinc finger. Choi, K.O., Lee, T., Lee, N., Kim, J.H., Yang, E.G., Yoon, J.M., Kim, J.H., Lee, T.G., Park, H. Mol. Pharmacol. (2005)
- Regulation of the prolyl hydroxylase domain protein 2 (phd2/egln-1) gene: identification of a functional hypoxia-responsive element. Metzen, E., Stiehl, D.P., Doege, K., Marxsen, J.H., Hellwig-Bürgel, T., Jelkmann, W. Biochem. J. (2005)
- Role of reactive oxygen species in angiotensin II-mediated renal growth, differentiation, and apoptosis. Wolf, G. Antioxid. Redox Signal. (2005)
- The androgen receptor is significantly associated with vascular endothelial growth factor and hypoxia sensing via hypoxia-inducible factors HIF-1a, HIF-2a, and the prolyl hydroxylases in human prostate cancer. Boddy, J.L., Fox, S.B., Han, C., Campo, L., Turley, H., Kanga, S., Malone, P.R., Harris, A.L. Clin. Cancer Res. (2005)
- Analysis of HIF-prolyl hydroxylases binding to substrates. Land??zuri, M.O., Vara-Vega, A., Vit??n, M., Cuevas, Y., del Peso, L. Biochem. Biophys. Res. Commun. (2006)
- Increased prolyl 4-hydroxylase domain proteins compensate for decreased oxygen levels. Evidence for an autoregulatory oxygen-sensing system. Stiehl, D.P., Wirthner, R., Köditz, J., Spielmann, P., Camenisch, G., Wenger, R.H. J. Biol. Chem. (2006)
- HIF prolyl hydroxylases in the rat; organ distribution and changes in expression following hypoxia and coronary artery ligation. William, C., Maxwell, P.H., Nichols, L., Lygate, C., Tian, Y.M., Bernhardt, W., Wiesener, M., Ratcliffe, P.J., Eckardt, K.U., Pugh, C.W. J. Mol. Cell. Cardiol. (2006)