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Bielsky, I.F. et al.

Bielsky, Hu, Ren, Terwilliger, Young,

The V1a vasopressin receptor is necessary and sufficient for normal social recognition: a gene replacement study.

Vasopressin modulates many social and nonsocial behaviors, including emotionality. We have previously reported that male mice with a null mutation in the V1a receptor (V1aR) exhibit a profound impairment in social recognition and changes in anxiety-like behavior. Using site-specific injections of a V1aR-specific antagonist, we demonstrate that the lateral septum, but not the medial amygdala, is critical for social recognition. Reexpressing V1aR in the lateral septum of V1aR knockout mice (V1aRKO) using a viral vector resulted in a complete rescue of social recognition. Furthermore, overexpression of the V1aR in the lateral septum of wild-type (wt) mice resulted in a potentiation of social recognition behavior and a mild increase in anxiety-related behavior. These results demonstrate that the V1aR in the lateral septum plays a critical role in the neural processing of social stimuli required for complex social behavior.[1]

References

The V1a vasopressin receptor is necessary and sufficient for normal social recognition: a gene replacement study. Bielsky, I.F., Hu, S.B., Ren, X., Terwilliger, E.F., Young, L.J. Neuron (2005) [Pubmed]

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