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Gene Review

Avpr1a  -  arginine vasopressin receptor 1A

Mus musculus

Synonyms: AVPR, AVPR V1a, Antidiuretic hormone receptor 1a, Avpr1, V1a, ...
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Disease relevance of Avpr1a


Psychiatry related information on Avpr1a


High impact information on Avpr1a

  • Increased affiliative response to vasopressin in mice expressing the V1a receptor from a monogamous vole [6].
  • Arginine vasopressin influences male reproductive and social behaviours in several vertebrate taxa through its actions at the V1a receptor in the brain [6].
  • These data indicate that the pattern of V1a-receptor gene expression in the brain may be functionally associated with species-typical social behaviours in male vertebrates [6].
  • Using site-specific injections of a V1aR-specific antagonist, we demonstrate that the lateral septum, but not the medial amygdala, is critical for social recognition [4].
  • In this study, we investigated the functional roles of the V1a receptor in cardiovascular homeostasis using gene targeting [7].

Biological context of Avpr1a

  • Arterial baroreceptor reflexes were markedly impaired in mutant mice, consistent with a loss of V1a receptors in the central area of baroreflex control [7].
  • Taken together, these results indicate that the V1a receptor plays an important role in normal resting arterial BP regulation mainly by its regulation of circulating blood volume and baroreflex sensitivity [7].
  • Although AVP is used clinically as a potent vasoconstrictor (V1a receptor-mediated) in patients with circulatory shock, the physiological role of vasopressin V1a receptors in blood pressure (BP) homeostasis is ill-defined [7].
  • The basal BP of conscious mutant mice lacking the V1a receptor gene (V1a-/-) was significantly (P < 0.001) lower compared to the wild-type mice (V1a+/+) without a notable change in heart rate [7].
  • 3. Inhibition of vasopressin-stimulated [3H]-IP and [3H]-PtdBuOH accumulation by the V1a receptor antagonists, Des-Gly9[beta-mercapto-beta,beta,-cyclopentamethylene propionyl, O-Et-Tyr2,Val4,Arg8]-vasopressin generated similar IC50 values suggesting that both these responses are mediated through the activation of a single V1a receptor subtype [8].

Anatomical context of Avpr1a


Associations of Avpr1a with chemical compounds

  • V1a vasopressin receptors maintain normal blood pressure by regulating circulating blood volume and baroreflex sensitivity [7].
  • Arginine-vasopressin (AVP) is a hormone that is essential for both osmotic and cardiovascular homeostasis, and exerts important physiological regulation through three distinct receptors, V1a, V1b, and V2 [7].
  • A radioligand binding study showed that SR49059 and OPC-21268 potently inhibited [3H]AVP binding to the cloned mouse V1a receptor, with Ki values of 27 and 510 nM, respectively, whereas SSR149415 potently inhibited [3H]AVP binding to the cloned mouse V1b receptor with a Ki value of 110 nM [11].
  • V1aR binding was nonoverlapping with each of these markers but colocalized with iron accumulation as shown by Perls' iron stain as well as leucine-enkephalin immunoreactivity, both markers for the ventral pallidum [5].
  • In HIT cell monolayers, the relative order of affinity of analogues in competition for binding with [3H]AVP was: dAVP > AVT = VP > V1a antagonist > OXY > dDAVP > V2 antagonist = d(D-3-Pal)VP, in parallel with their biological activity [13].

Other interactions of Avpr1a

  • To determine the extent to which these receptors mediate the behavioral effects of alcohol, we used mice with targeted disruptions of either their Avpr1a or Avpr1b gene [1].
  • A potential cellular basis for these effects is the species-specific pattern of expression of oxytocin and V1a receptor in reward pathways of the prairie vole brain [14].
  • The unique promoter sequences of the prairie vole OTR and V1a receptor genes and the resulting species-specific pattern of regional expression provide a potential molecular mechanism for the evolution of pair bonding behaviors and a cellular basis for monogamy [14].

Analytical, diagnostic and therapeutic context of Avpr1a

  • To provide further insight into the physiological role of V1a and V2 vasopressin receptors in the human and mouse kidney, intrarenal localization of the receptors mRNA was determined by in situ hybridization [15].


  1. The acute intoxicating effects of ethanol are not dependent on the vasopressin 1a or 1b receptors. Caldwell, H.K., Stewart, J., Wiedholz, L.M., Millstein, R.A., Iacangelo, A., Holmes, A., Young, W.S., Wersinger, S.R. Neuropeptides (2006) [Pubmed]
  2. AVP receptors of mouse Leydig cells are regulated by LH and E2 and influenced by experimental cryptorchidism. Tahri-Joutei, A., Pointis, G. FEBS Lett. (1989) [Pubmed]
  3. Profound impairment in social recognition and reduction in anxiety-like behavior in vasopressin V1a receptor knockout mice. Bielsky, I.F., Hu, S.B., Szegda, K.L., Westphal, H., Young, L.J. Neuropsychopharmacology (2004) [Pubmed]
  4. The V1a vasopressin receptor is necessary and sufficient for normal social recognition: a gene replacement study. Bielsky, I.F., Hu, S.B., Ren, X., Terwilliger, E.F., Young, L.J. Neuron (2005) [Pubmed]
  5. Ventral striatopallidal oxytocin and vasopressin V1a receptors in the monogamous prairie vole (Microtus ochrogaster). Lim, M.M., Murphy, A.Z., Young, L.J. J. Comp. Neurol. (2004) [Pubmed]
  6. Increased affiliative response to vasopressin in mice expressing the V1a receptor from a monogamous vole. Young, L.J., Nilsen, R., Waymire, K.G., MacGregor, G.R., Insel, T.R. Nature (1999) [Pubmed]
  7. V1a vasopressin receptors maintain normal blood pressure by regulating circulating blood volume and baroreflex sensitivity. Koshimizu, T.A., Nasa, Y., Tanoue, A., Oikawa, R., Kawahara, Y., Kiyono, Y., Adachi, T., Tanaka, T., Kuwaki, T., Mori, T., Takeo, S., Okamura, H., Tsujimoto, G. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  8. Vasopressin-stimulated [3H]-inositol phosphate and [3H]-phosphatidylbutanol accumulation in A10 vascular smooth muscle cells. Plevin, R., Stewart, A., Paul, A., Wakelam, M.J. Br. J. Pharmacol. (1992) [Pubmed]
  9. Vasopressin regulation of the proestrous luteinizing hormone surge in wild-type and clock mutant mice. Miller, B.H., Olson, S.L., Levine, J.E., Turek, F.W., Horton, T.H., Takahashi, J.S. Biol. Reprod. (2006) [Pubmed]
  10. Arginine vasopressin (AVP) replacement of helper cell requirement in IFN-gamma production. Evidence for a novel AVP receptor on mouse lymphocytes. Torres, B.A., Johnson, H.M. J. Immunol. (1988) [Pubmed]
  11. Vasopressin stimulates insulin release from islet cells through V1b receptors: a combined pharmacological/knockout approach. Oshikawa, S., Tanoue, A., Koshimizu, T.A., Kitagawa, Y., Tsujimoto, G. Mol. Pharmacol. (2004) [Pubmed]
  12. Effect of a new, potent, non-peptide V1a vasopressin antagonist, SR 49059, on the binding and the mitogenic activity of vasopressin on Swiss 3T3 cells. Serradeil-Le Gal, C., Bourrié, B., Raufaste, D., Carayon, P., Garcia, C., Maffrand, J.P., Le Fur, G., Casellas, P. Biochem. Pharmacol. (1994) [Pubmed]
  13. Similarities between hamster pancreatic islet beta (HIT) cell vasopressin receptors and V1b receptors. Richardson, S.B., Laya, T., VanOoy, M. J. Endocrinol. (1995) [Pubmed]
  14. Oxytocin, vasopressin, and the neuroendocrine basis of pair bond formation. Insel, T.R., Winslow, J.T., Wang, Z., Young, L.J. Adv. Exp. Med. Biol. (1998) [Pubmed]
  15. Axial heterogeneity of vasopressin-receptor subtypes along the human and mouse collecting duct. Carmosino, M., Brooks, H.L., Cai, Q., Davis, L.S., Opalenik, S., Hao, C., Breyer, M.D. Am. J. Physiol. Renal Physiol. (2007) [Pubmed]
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