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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Leptin downregulates ghrelin levels in streptozotocin-induced diabetic mice.

Ghrelin, an orexigenic peptide produced in the stomach, is increased in streptozotocin (STZ)-induced diabetic (DM) mice. This study clarifies the regulation of ghrelin levels by leptin in STZ-DM mice. STZ-DM mice had higher plasma ghrelin concentrations and greater ghrelin mRNA expression than control mice. Changes in ghrelin levels were dose dependently attenuated by the subcutaneous injection of leptin (0-27 nmol x kg(-1) x day(-1) over 7 days). Leptin treatment also partially reversed the hyperphagia and hyperglycemia observed in STZ-DM mice, but not the hypoinsulinemia, and there was a decrease in plasma ghrelin concentrations and ghrelin mRNA levels compared with STZ-LEP pair-fed mice. These results indicate that leptin treatment partially reverses elevated plasma ghrelin levels in STZ-DM mice independent of food intake and insulin, and suggest that hypoleptinemia in STZ-DM mice upregulates ghrelin.[1]


  1. Leptin downregulates ghrelin levels in streptozotocin-induced diabetic mice. Tsubone, T., Masaki, T., Katsuragi, I., Tanaka, K., Kakuma, T., Yoshimatsu, H. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2005) [Pubmed]
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