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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Cholesterol-depleting compounds modulate K+-currents in Drosophila Kenyon cells.

Sterol-enriched lipid rafts have been involved in Drosophila membrane signalling such as Hedgehog targeting and glutamate receptor ligand-affinity regulation. Here, we show that the voltage-dependent K(+) currents expressed by the intrinsic neurons of the Mushroom bodies are upward-modulated by compounds that remove sterols from the plasma membrane. Modulation seems to rely on a fast-exchanging sterol-pool, which more strongly affects the slowly inactivating current. Our results provide the first evidence that sterols influence the operation of voltage-gated ion channels in Drosophila neurons and strengthen the importance of lipid rafts in this biological model.[1]


  1. Cholesterol-depleting compounds modulate K+-currents in Drosophila Kenyon cells. Gasque, G., Labarca, P., Darszon, A. FEBS Lett. (2005) [Pubmed]
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