Disease relevance of Models, Biological

• A biological model (experimental myocardial infarction in rabbit) was used to estimate the relative importance of different factors (liposome size and coating with protective polymer and/or specific antibody) for effective accumulation of liposomes in the target [1].
• Aberrations in cell proliferation, oxidative damage, and DNA-repair fidelity have been implicated in sodium arsenite (AsIII)-mediated carcinogenicity and toxicity, but these events have been examined in isolation in the majority of biological models of arsenic exposure [2].
• Current biological models of panic disorder (PD) assert that this disorder is maintained by hypersensitivity to carbon dioxide (CO2) and related asphyxia cues, which is manifested as an exaggerated suffocation alarm (D. Klein, 1993) [3].

Psychiatry related information on Models, Biological

• A biologic model to study the genetics of psychotic, mood, and anxiety disorders: the velocardiofacial syndrome [4].

High impact information on Models, Biological

• Retinoblastoma is a prototype biological model for the study of such recessive oncogenes [5].
• An existing picosecond time-of-flight and absorbance (TOFA) optical system has been used to image a model biologic system and a rat [6].
• Biological models and genes of tumor reversion: cellular reprogramming through tpt1/TCTP and SIAH-1 [7].
• Here we use a biological model in which HOXB6 represses alpha- and gamma-globin mRNA levels to perform a structure/function analysis for this homeodomain protein [8].
• Taken together, these data provide a cell biological model of SOD1 biosynthesis that is consistent with the concept of limited intracellular copper availability and indicate that the metallochaperone CCS is a critical determinant of SOD1 activity in mammalian cells [9].

Chemical compound and disease context of Models, Biological

• Toxicity of aluminium in biological model systems [10].
• Toxicity of the ammonium nitrate NH4NO3 on the respiratory metabolism of three biological models: parameciums, mosses and lichens [11].

Biological context of Models, Biological

• The Ca(2+) influx, caused by the porin treatment of SVC1 cells, appears to play an important role in the triggering of apoptosis in our biological model [12].
• Prenatal ethanol exposure can lead to long-lasting impairments in the ability to process spatial information in rats, as well as produce long-lasting deficits in the ability of animals to exhibit long-term potentiation, a biological model of learning and memory processing [13].
• The very high binding capacity of human and rat platelets (Bmax greater than pmole/10(8) cells) makes them a good biological model for studying the physiological significance of "peripheral type" benzodiazepine binding sites [14].
• Murine macrophage cell line J774A.1, expressing high levels of SIRPalpha, was selected as the biologic model system for phagocytosis [15].
• The biological model investigated was the phosphorylation of myosin light chain in a cell free system [16].

Anatomical context of Models, Biological

• Behavior of tetrahydrolipstatin in biological model membranes and emulsions [17].
• The mechanism of inhibition of I- accumulation in the thyroid by valinomycin was investigated on a biological model [18].
• An interesting aspect of this biological model lies in the ability of regenerates to differentiate the spinal cord (SC), the vertebral cartilage, and muscles [19].
• Blood-brain barrier partitioning is found to depend upon the polar surface area. the octanol/water partition coefficient, and the conformational flexibility of the compounds as well as the strength of their binding" to the model biologic membrane [20].
• The in vitro biological models used in the present study included the SW1088, U87 and U373 astrocytic tumor cell lines [21].

Associations of Models, Biological with chemical compounds

• Thus, H. halobium is a unique biological model which allows one to study the regulation of intracellular HMG-CoA concentration and not HMG-CoA reductase activity (content) in response to mevalonate availability [22].
• Identification of glucose response proteins in two biological models of beta-cell adaptation to chronic high glucose exposure [23].
• Halobacterium halobium was evaluated as a potentially simpler biological model to study the regulation of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase activity (content) in response to mevalonate availability [22].
• OBJECTIVE: The serotonin system has long been of interest in biological models of human personality [24].
• Melatonin has been shown to act as a radical scavenger in various chemical and biological model systems in vitro [25].

Gene context of Models, Biological

• In the present work, we have investigated the expression of both c-ets 1 and u-PA, a putative target gene of the Ets 1 proteins, within a biological model which includes both embryonic and tumoral aspects [26].
• These animals may therefore serve as a useful biological model for investigating the importance of AVP in the ACTH and beta-END response to HA and stress [27].
• On the basis of differences in the potencies and intrinsic activity of 5-HT4 receptor agonists in different biological models it has been suggested that there is heterogeneity among 5-HT4 receptors [28].
• IL-1 exists in two forms, termed IL-1alpha and IL-1beta, which exert similar effects in a number of biologic models [29].
• Gonadal development and differentiation is dependent in part on GH, as GH deficiency has been implicated as a cause of lowered fertility and spermatogenic cessation in humans and some biological models [30].

Analytical, diagnostic and therapeutic context of Models, Biological

• Because of the difficulty in translating the mathematical analysis of various compartments into the biological model, biodistribution was monitored by a gamma camera linked to a DEC PDP 11/34 computer system [31].
• In the present study, immunoelectron microscopy and immunofluorescence analyses were performed with these two mAbs to determine the expression and distribution of glutamylated tubulin isoforms in selected biological models whose tubulin isotypes are characterized [32].
• Toxicological damage to the biological models associated with exposure to monocaprin was assessed by scanning electron microscopy and by the measurement of lactate dehydrogenase (LDH) release from everted gut sacs [33].
• Such analytical tests provide an alternative to animal models for Quality Control Laboratories; biological models can be difficult and costly to develop and use on a routine basis [34].
• In situ hybridization (ISH) was then used as a useful biological model for RCM to test the optimal conditions for DAB staining found in the model system (high concentrations of DAB and peroxidase and 2 h incubation time) [35].

References