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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Mutation at the "exit gate" of the salmonella gyrase a subunit suppresses a defect in the gyrase B subunit.

In Salmonella enterica serovar Typhimurium, an S431P substitution in the B subunit of gyrase (allele gyrB651) confers resistance to nalidixic acid and causes reduced DNA superhelicity and hypersensitivity to novobiocin. Selection for novobiocin resistance allowed isolation of a mutation in the gyrA gene (allele gyrA659), a T467S substitution, which partially suppresses the supercoiling defect of gyrB651. Modeling analysis suggests that this mutation acts by destabilizing the GyrA bottom dimer interface. This is the first example of a gyrA mutation that compensates for a gyrB defect.[1]

References

  1. Mutation at the "exit gate" of the salmonella gyrase a subunit suppresses a defect in the gyrase B subunit. Blanc-Potard, A.B., Labesse, G., Figueroa-Bossi, N., Bossi, L. J. Bacteriol. (2005) [Pubmed]
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