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Gene Review

gyrB  -  DNA gyrase subunit B

Salmonella enterica subsp. enterica serovar Typhimurium str. LT2

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Disease relevance of gyrB

  • Additionally, antibiotic-susceptible strains of serotypes other than Salmonella enterica serovar Typhimurium strains were examined for serotype-specific mutations in gyrB (n = 4), parC (n = 6) and parE (n = 1) [1].
  • The detection is specific; the sensor does not respond when challenged with control oligonucleotides based on the gyrB genes of either Escherichia coli or various Shigella species [2].

High impact information on gyrB

  • Mutations affecting DNA topoisomerase I (topA) in Salmonella typhimurium were isolated and graded on the basis of their ability to reverse the effects of gyrB mutations on his operon expression [3].
  • No mutations were found in the gyrB, parC, and parE genes [4].
  • This is the first example of a gyrA mutation that compensates for a gyrB defect [5].
  • Evidence supports isoleucine as a positive effector on valine sensitive AHAS expression and that the gyrB mutation accentuates the isoleucine effect [6].

Biological context of gyrB

  • Different topA and gyrB alleles (in otherwise isogenic strains) were used to gather insights into the transcription-dependent variability of plasmid DNA-linking deficit in growing bacteria [3].


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