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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Human Bex2 interacts with LMO2 and regulates the transcriptional activity of a novel DNA-binding complex.

Human Bex2 (brain expressed X-linked, hBex2) is highly expressed in the embryonic brain, but its function remains unknown. We have identified that LMO2, a LIM-domain containing transcriptional factor, specifically interacts with hBex2 but not with mouse Bex1 and Bex2. The interaction was confirmed both by pull-down with GST-hBex2 and by coimmunoprecipitation assays in vivo. Using electrophoretic mobility shift assay, we have demonstrated the physical interaction of hBex2 and LMO2 as part of a DNA-binding protein complex. We have also shown that hBex2 can enhance the transcriptional activity of LMO2 in vivo. Furthermore, using mammalian two-hybrid analysis, we have identified a neuronal bHLH protein, NSCL2, as a novel binding partner for LMO2. We then showed that LMO2 could up-regulate NSCL2-dependent transcriptional activity, and hBex2 augmented this effect. Thus, hBex2 may act as a specific regulator during embryonic development by modulating the transcriptional activity of a novel E-box sequence-binding complex that contains hBex2, LMO2, NSCL2 and LDB1.[1]


  1. Human Bex2 interacts with LMO2 and regulates the transcriptional activity of a novel DNA-binding complex. Han, C., Liu, H., Liu, J., Yin, K., Xie, Y., Shen, X., Wang, Y., Yuan, J., Qiang, B., Liu, Y.J., Peng, X. Nucleic Acids Res. (2005) [Pubmed]
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