Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

BEX1 - brain expressed, X-linked 1

Homo sapiens

Synonyms: BEX2, Brain-expressed X-linked protein 1, HBEX2, HGR74-h, Protein BEX1

Foltz, G. et al., Yang, Q.S. et al., Quentmeier, H. et al.

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Disease relevance of BEX1

Expression of BEX1 in acute myeloid leukemia with MLL rearrangements [1].
Genome-wide analysis of epigenetic silencing identifies BEX1 and BEX2 as candidate tumor suppressor genes in malignant glioma [2].

High impact information on BEX1

Viral-mediated reexpression of either BEX1 or BEX2 led to increased sensitivity to chemotherapy-induced apoptosis and potent tumor suppressor effects in vitro and in a xenograft mouse model [2].
The BEX1 gene was localized to chromosome band Xq22 between markers between DXS990 and DXS1059 by screening Stanford radiation hybrid G3 panels [3].
In situ hybridization of mouse testis using BEX1 as a probe detected the signal in the pachytene spermatocytes and spermatids but not in spermatogonia [3].

References

Expression of BEX1 in acute myeloid leukemia with MLL rearrangements. Quentmeier, H., Tonelli, R., Geffers, R., Pession, A., Uphoff, C.C., Drexler, H.G. Leukemia (2005) [Pubmed]
Genome-wide analysis of epigenetic silencing identifies BEX1 and BEX2 as candidate tumor suppressor genes in malignant glioma. Foltz, G., Ryu, G.Y., Yoon, J.G., Nelson, T., Fahey, J., Frakes, A., Lee, H., Field, L., Zander, K., Sibenaller, Z., Ryken, T.C., Vibhakar, R., Hood, L., Madan, A. Cancer Res. (2006) [Pubmed]
Cloning and expression pattern of a spermatogenesis-related gene, BEX1, mapped to chromosome Xq22. Yang, Q.S., Xia, F., Gu, S.H., Yuan, H.L., Chen, J.Z., Yang, Q.S., Ying, K., Xie, Y., Mao, Y.M. Biochem. Genet. (2002) [Pubmed]

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