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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

BEX2  -  brain expressed X-linked 2

Homo sapiens

Synonyms: BEX1, Brain-expressed X-linked protein 2, DJ79P11.1, Protein BEX2, hBex2
 
 
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Disease relevance of BEX2

 

High impact information on BEX2

  • Viral-mediated reexpression of either BEX1 or BEX2 led to increased sensitivity to chemotherapy-induced apoptosis and potent tumor suppressor effects in vitro and in a xenograft mouse model [1].
  • We have also shown that hBex2 can enhance the transcriptional activity of LMO2 in vivo [3].
 

Associations of BEX2 with chemical compounds

  • BEX2 overexpression enhances the antiproliferative effect of tamoxifen at pharmacologic dose (1 micromol/L) [4].
 

Other interactions of BEX2

References

  1. Genome-wide analysis of epigenetic silencing identifies BEX1 and BEX2 as candidate tumor suppressor genes in malignant glioma. Foltz, G., Ryu, G.Y., Yoon, J.G., Nelson, T., Fahey, J., Frakes, A., Lee, H., Field, L., Zander, K., Sibenaller, Z., Ryken, T.C., Vibhakar, R., Hood, L., Madan, A. Cancer Res. (2006) [Pubmed]
  2. Epigenetic regulation of brain expressed X-linked-2, a marker for acute myeloid leukemia with mixed lineage leukemia rearrangements. Fischer, C., Drexler, H.G., Reinhardt, J., Zaborski, M., Quentmeier, H. Leukemia (2007) [Pubmed]
  3. Human Bex2 interacts with LMO2 and regulates the transcriptional activity of a novel DNA-binding complex. Han, C., Liu, H., Liu, J., Yin, K., Xie, Y., Shen, X., Wang, Y., Yuan, J., Qiang, B., Liu, Y.J., Peng, X. Nucleic Acids Res. (2005) [Pubmed]
  4. BEX2 is overexpressed in a subset of primary breast cancers and mediates nerve growth factor/nuclear factor-kappaB inhibition of apoptosis in breast cancer cell lines. Naderi, A., Teschendorff, A.E., Beigel, J., Cariati, M., Ellis, I.O., Brenton, J.D., Caldas, C. Cancer Res. (2007) [Pubmed]
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